Recombinant Bream GH Protein
Cat.No. : | GH-780B |
Product Overview : | Recombinant Bream Growth Hormone Binding Protein (P29971) was expressed in E. coli. |
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Description : | The Growth Hormone (GH) is a polypeptide that is secreted by the adenohypophysis. Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized. GH augments the cytolytic activity of T-cells, antibody synthesis, and granulocyte differentiation induced by GM-CSF. GH also enhances production of TNF-alpha, generation of superoxide anions from peritoneal macrophages, and natural killer activity. Recombinant bream GH produced in E. coli is a single, non-glycosylated, polypeptide chain containing having a molecular mass of 21.41 kDa. Bream GH shares 97% amino acid sequence identity with gilthead sea bream, 94% with red sea bream, 93% with the tuna, 91% with barramundi and 63% with the salmon. The GH is purified by proprietary chromatographic techniques. |
Source : | E. coli |
Species : | Bream |
Molecular Mass : | 21 kDa |
Endotoxin : | Less than 0.1 ng/μg (IEU/μg) of GH. |
Purity : | > 95 % (SDS-PAGE, RP-HPLC) |
Storage : | Store at -20 centigrade, avoid freeze/thaw cycles. |
Official Symbol : | GH |
Synonyms : | GH; Growth Hormone Binding Protein |
UniProt ID : | P18075 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIn the treatment of certain diseases, such as growth hormone deficiency and dwarfism, replacement therapy can be achieved with the use of GH protein or its analogues to promote the growth and development of the body.
Studying the regulation of gene expression of GH protein can be achieved through the study of gene transcription, post-transcriptional modification, and translation. For example, it can be done by detecting the expression and activity of transcription factors, or by studying the effects of epigenetic modifications on GH gene expression.
There are complex interactions between GH protein and other hormones. For example, GH protein can stimulate the secretion of insulin-like growth factor-1 (IGF-1), which in turn regulates GH secretion. In addition, GH can also interact with sex hormones to affect the body's growth and metabolic processes.
In clinical practice, the diagnosis of diseases such as growth hormone deficiency, gigantism, and acromegaly can be guided by detecting the level or gene sequence of GH protein, as well as stimulation tests on GH protein. At the same time, based on the structural and functional characteristics of GH proteins, new drugs can be developed to treat these diseases.
The diagnosis of growth hormone deficiency requires a series of laboratory tests, including GH stimulation test, insulin tolerance test, and serum insulin-like growth factor-1 (IGF-1) level. These tests can help your doctor determine whether you have a growth hormone deficiency.
The structure and function of GH proteins are closely related. Its specific amino acid sequence and spatial conformation determine its ability to bind to receptors and activate receptors. Therefore, the understanding of the structure and function of GH protein can help in the development of new drug designs and treatments.
Customer Reviews (3)
Write a reviewDue to its high activity, the experiment can be successful in the first time, reducing the number of experiments.
Fluorescent labeling works well and helps with imaging studies.
The high yield and high purity facilitate our large-scale experiments.
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