Recombinant Canine IL6 protein, His-tagged
Cat.No. : | IL6-144C |
Product Overview : | Recombinant Canine IL6(21-207aa) fused with His tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | IL6, as known as Interleukin-6, is a phosphorylated and variably glycosylated cytokine. It is secreted by T cells and macrophages to stimulate immune response during infection and after trauma, especially burns or other tissue damage leading to inflammation. Also, this protein can function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. |
Source : | Insect cells |
Species : | Canine |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 22.0kDa (195aa) 18-28kDa (SDS-PAGE under reducing conditions.) |
AA Sequence : | FPTPGPLAGD SKDDATSNSL PLTSANKVEE LIKYILGKIS ALRKEMCDKF NKCEDSKEAL AENNLHLPKL EGKDGCFQSG FNQETCLTRI TTGLVEFQLH LNILQNNYEG DKENVKSVHM STKILVQMLK SKVKNQDEVT TPDPTTDASL QAILQSQDEC VKHTTIHLIL RSLEDFLQFS LRAVRIMLEH HHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | > 95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Bradford assay) |
Gene Name : | IL6 interleukin 6 [ Canis lupus familiaris ] |
Official Symbol : | IL6 |
Synonyms : | IL-6; interleukin-6; interleukin 6 (interferon, beta 2) |
Gene ID : | 403985 |
mRNA Refseq : | NM_001003301 |
Protein Refseq : | NP_001003301 |
UniProt ID : | P41323 |
Chromosome Location : | IL-6 |
Pathway : | AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem; Antifolate resistance, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem |
Function : | cytokine activity; interleukin-6 receptor binding; growth factor activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
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