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Recombinant Cynomolgus ADRB2 Protein, His-tagged

Cat.No. : ADRB2-280C
Product Overview : Recombinant Cynomolgus ADRB2 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Cynomolgus
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : ADRB2 adrenoceptor beta 2, surface [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : ADRB2
Synonyms : ADRB2; adrenergic receptor beta 2;
Gene ID : 102144318
mRNA Refseq : NM_001287285
Protein Refseq : NP_001274214
MIM :
UniProt ID : G7P8M7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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How are drugs that target ADRB2 receptors used in disease treatment? 02/04/2023

Drugs that target ADRB2 receptors, known as beta-2 agonists, are commonly used in the treatment of asthma, COPD, and other respiratory diseases. Selective ADRB2 agonists such as salmeterol and formoterol have also been used to treat chronic heart failure and metabolic disorders such as diabetes and obesity. However, chronic activation of ADRB2 signaling can lead to receptor desensitization and potentially adverse effects such as cardiac arrhythmias and metabolic dysfunction.

How do ADRB2 receptors impact exercise performance? 04/12/2022

ADRB2 receptors play a role in regulating exercise performance by mediating the effects of adrenaline and noradrenaline on the cardiovascular and respiratory systems. Activation of ADRB2 receptors can increase heart rate and blood flow to the muscles, as well as dilate the airways to improve oxygen uptake. Polymorphisms in the ADRB2 gene have been associated with differences in exercise performance, with some variants associated with improved endurance and others with decreased performance.

How do ADRB2 receptors impact cardiac function? 08/15/2021

ADRB2 receptors are primarily expressed in the heart's ventricular muscle tissue, where they regulate heart rate and contractility. Activation of ADRB2 receptors can increase heart rate and contractility, while desensitization of these receptors can lead to reduced cardiac function and increased risk of heart failure. Polymorphisms in the ADRB2 gene have also been associated with differences in risk of cardiovascular disease and response to beta blocker therapy.

What are polymorphisms in the ADRB2 gene and how do they impact drug response? 07/17/2021

Polymorphisms are variations in the DNA sequence of a gene that can lead to differences in protein expression or function. Several polymorphisms have been identified in the ADRB2 gene, some of which have been shown to impact drug response. For example, the Arg16Gly and Gln27Glu polymorphisms have been associated with decreased response to beta-2 agonist drugs in asthma patients. Other polymorphisms, such as the Thr164Ile and Gly16Arg variants, have been associated with improved treatment response.

What are the potential side effects of drugs that target ADRB2 receptors? 12/01/2020

Some potential side effects of drugs that target ADRB2 receptors include tremors or shakiness, increased heart rate, insomnia, and arrhythmias. Long-term use of ADRB2 agonists can also lead to receptor desensitization and decreased response to therapy over time. In rare cases, severe allergic reactions or bronchospasm can occur.

How do ADRB2 receptors impact bone density? 06/20/2018

ADRB2 receptors are also expressed in bone cells, where they play a role in regulating bone density. Activation of ADRB2 receptors can stimulate the formation of new bone cells and increase bone mineral density, while receptor desensitization can result in decreased bone density and increased risk of osteoporosis. Polymorphisms in the ADRB2 gene have also been associated with differences in bone density and risk of osteoporosis.

How are ADRB2 antagonists used in asthma treatment? 02/10/2018

ADRB2 antagonists, also known as beta blockers, are not used to treat asthma as they can exacerbate airway constriction. Instead, short-acting ADRB2 agonists such as albuterol are used to relieve bronchospasms and improve breathing, while long-acting ADRB2 agonists such as salmeterol are used as maintenance therapy to prevent asthma symptoms.

How are ADRB2 agonists used in labor and delivery? 12/06/2017

ADRB2 agonists such as terbutaline and ritodrine are sometimes used during labor to relax the uterus and prevent preterm labor. However, the use of these drugs for this purpose is controversial due to concerns about potential side effects such as maternal heart failure and fetal tachycardia. These drugs are typically administered as a temporary measure until other interventions such as corticosteroids can be used.

How do drugs that target ADRB2 receptors interact with other medications? 07/05/2017

Drugs that target ADRB2 receptors can interact with other medications that impact the sympathetic nervous system, such as beta blockers or alpha-adrenergic agonists. For example, taking a beta blocker along with a beta-2 agonist can lead to decreased effectiveness of the beta-2 agonist. Additionally, some medications such as monoamine oxidase inhibitors (MAOIs) can lead to increased norepinephrine levels and potentially severe cardiovascular effects when taken with ADRB2 agonists.

Can ADRB2 agonists be used for weight loss? 05/18/2017

ADRB2 agonists have been studied for their potential as weight loss aids, as they can increase metabolic rate and promote lipolysis (the breakdown of fat). However, long-term use of ADRB2 agonists for weight loss is not recommended due to the risk of side effects such as cardiac arrhythmias and increased blood pressure.

Are there any alternative treatments for conditions that are commonly treated with ADRB2 agonists? 02/19/2017

Alternative treatments for conditions such as asthma and COPD include inhaled corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). Newer medications targeting different pathways, such as muscarinic receptor antagonists, have also been approved for the treatment of COPD. In some cases, lifestyle modifications such as smoking cessation and weight loss can also improve respiratory symptoms and reduce the need for medications.

How do ADRB2 receptors impact mood? 10/21/2016

ADRB2 receptors are also involved in regulating mood, with activation of these receptors being associated with increased feelings of alertness and arousal. Polymorphisms in the ADRB2 gene have been associated with differences in mood, including risk of depression and anxiety disorders. ADRB2 agonists such as salbutamol have been studied for their potential as mood enhancers, but further research is needed to confirm their efficacy and safety in this context.

How do ADRB2 agonists impact glucose metabolism? 07/12/2016

ADRB2 agonists can influence glucose metabolism by promoting glycogenolysis (the breakdown of stored glucose) and stimulating insulin secretion from pancreatic beta cells. Long-term use of ADRB2 agonists has been associated with increased risk of insulin resistance and type 2 diabetes, likely due to receptor desensitization and downregulation of insulin receptors.

Customer Reviews (4)

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Reviews
09/18/2020

    The ADRB2 protein is of exceptional quality and is perfectly suited for my experimental requirements.

    09/24/2019

      Their excellent technical support has helped me overcome any challenges I have encountered, and I have full faith in their products and services.

      06/29/2018

        I am confident that this product will deliver accurate and reliable results.

        05/19/2018

          I look forward to continuing to work with them in the future and exploring their other offerings.

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