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Active Recombinant Cynomolgus ICOSLG protein, His-tagged

Cat.No. : ICOSLG-291C
Product Overview : Recombinant Cynomolgus ICOSLG protein(XP_005548618.1)(Met1-Thr256), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Cynomolgus
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : Immobilized Recombinant Rhesus ICOS / AILIM / CD278 Protein (Fc Tag) at 2 μg/ml (100 μl/well) can bind Recombinant Cynomolgus ICOS Ligand / B7-H2 / ICOSLG Protein (ECD,His Tag),The EC50 is 3-12 ng/mL.
Molecular Mass : The recombinant cynomolgus ICOSLG consists 249 amino acids and predicts a molecular mass of 28.1 kDa.
Protein Length : Met1-Thr256
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to evaluate the role of icosg proteins in the immune system? 10/06/2022

ICOSLG protein plays an important regulatory role in the immune system. It binds to ICOS receptors on the surface of T cells and promotes the activation and differentiation of T cells, which in turn affects the strength and direction of the immune response.

Which biomolecules can be used as molecular markers for ICOSLG proteins? 02/25/2022

Certain biomolecules can serve as molecular markers of ICOSLG proteins, such as mRNAs or proteins of ICOSLG proteins detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What factors need to be considered in drug development for ICOSLG proteins? 12/10/2020

Factors to be considered in drug development for ICOSLG proteins include drug specificity, safety, pharmacokinetic properties, etc. In addition, the dosage form, route of administration, and dosage of the drug need to be considered to develop an effective treatment plan.

What factors can affect the expression of ICOSLG protein? 06/09/2020

A variety of factors can affect the expression of ICOSLG protein, including cytokines, inflammatory factors, immunostimulants, etc. These factors can stimulate or inhibit the expression of ICOSLG protein, which in turn affects the strength and direction of the immune response.

What are the therapeutic strategies for ICOSLG protein? 05/06/2020

Therapeutic strategies targeting ICOSLG proteins include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against ICOSLG protein to inhibit its aberrant activity in disease, or the regulation of ICOSLG protein expression through gene knockout or overexpression technology.

How to evaluate the potential of ICOSLG protein as a drug target? 02/21/2020

Assessing the potential of ICOSLG proteins as drug targets requires a comprehensive analysis. Factors to consider include the structure and function of the ICOSLG protein, its role in the immune system, interactions with existing medications, and potential therapeutic efficacy and safety.

Customer Reviews (3)

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12/17/2022

    ICOSLG performed very well in the experiments, with reliable and reproducible results.

    11/14/2021

      The stability is very strong, and it can maintain the stability of its structure and function even after a lot of use, which shows its excellent quality and reliability.

      06/30/2020

        The storage conditions are simple, and it will not be denatured even at ultra-low temperatures.

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