Active Recombinant Cynomolgus Monkey FCGR2A protein, His-tagged
Cat.No. : | FCGR2A-270C |
Product Overview : | Recombinant Cynomolgus Monkey FCGR2A(Thr29-Ile211) fused with His tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
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Description : | Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation. The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI/CD64, Fc gamma RII/CD32, and Fc gamma RIII/CD16. CD32 proteins are encoded by three genes in human (Fc gamma RII A, B, and C), two in cynomolgus (Fc gamma RII A and B), and one in mouse (Fc gamma RIIB). Fc gamma RII A and C contain ITAM sequences, while Fc gamma RIIB contains an ITIM sequence in their cytoplasmic domains. The CD64 proteins are high affinity receptors (~10-8-10-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10-6-10-7 M) and only recognize IgG aggregates surrounding multivalent antigens. Mature cynomolgus Fc gamma RIIA consists of a 183 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 23 aa transmembrane segment, and a 77 aa cytoplasmic domain. Within the ECD, cynomolgus Fc gamma RIIA shares 89% aa sequence identity with human Fc gamma RIIA. It binds cynomolgus and human IgG subclasses 1-4 as well as human Pentraxin-2, and C-Reactive Protein. It delivers activating signals through its cytoplasmic ITAM sequence. Fc gamma RIIA signaling cooperates with Integrin alpha 2b beta 3 and the CD42b-GP1b-IX-V complex to promote platelet adhesion and activation. Fc gamma RIIA is expressed on monocytes, monocytes, and platelets and additionally on cynomolgus granulocytes. |
Source : | HEK293 |
Species : | Cynomolgus Monkey |
Tag : | His |
Predicted N Terminal : | Thr29 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Cynomolgus Monkey Fc gamma RIIA/CD32a is immobilized on a His Tag Antibody coated plate, it binds Biotinylated Human IgG. The concentration of Biotinylated Human IgG that produces 50% of the optimal binding response is approximately 0.75-3.75 μg/mL. |
Molecular Mass : | Predicted Molecular Mass: 21 kDa SDS-PAGE: 23-32 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 200 μg/mL in PBS. |
Gene Name : | FCGR2A Fc fragment of IgG receptor IIa [ Macaca fascicularis ] |
Official Symbol : | FCGR2A |
Synonyms : | FCGR2A; Fc fragment of IgG receptor IIa |
Gene ID : | 102143568 |
mRNA Refseq : | NM_001283669 |
Protein Refseq : | NP_001270598 |
Products Types
◆ Recombinant Protein | ||
FCGR2A-301H | Recombinant Human FCGR2A Protein, His-tagged | +Inquiry |
FCGR2A-542H | Recombinant Human FCGR2A Protein (R167) | +Inquiry |
FCGR2A-06H | Active Recombinant Human FCGR2A Protein, His-tagged | +Inquiry |
FCGR2A-17H | Active Recombinant Human FCGR2A (R167H) Protein (30-218aa), C-His-tagged | +Inquiry |
FCGR2A-384H | Active Recombinant Human FCGR2A Protein (R167) (Ala 36 - Ile 218), His & Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
FCGR2A-1996HCL | Recombinant Human FCGR2A cell lysate | +Inquiry |
FCGR2A-1926CCL | Recombinant Cynomolgus FCGR2A cell lysate | +Inquiry |
FCGR2A-001HCL | Recombinant Human FCGR2A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.
FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.
FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.
Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.
FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.
Customer Reviews (3)
Write a reviewWith its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.
Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.
The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.
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