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Recombinant Human A2M protein, His-tagged

Cat.No. : A2M-5731H
Product Overview : Recombinant Human A2M aa. (Ser616~Val856 (Accession # P01023)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 30kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser616~Val856 (Accession # P01023)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.7.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : A2M alpha-2-macroglobulin [ Homo sapiens (human) ]
Official Symbol : A2M
Synonyms : A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M
Gene ID : 2
mRNA Refseq : NM_000014.5
Protein Refseq : NP_000005.2
UniProt ID : P01023

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What role does A2M protein play in the immune system? 12/18/2022

It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

What is the relationship between A2M protein and lung disease? 09/29/2022

Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

In which organs or tissues are A2M proteins expressed high? 08/12/2021

The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

How does A2M protein remove harmful proteins from the body? 10/14/2020

Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

Can A2M protein be used as a potential therapeutic target for cardiovascular disease? 06/13/2020

A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

In which neurological diseases are A2M proteins studied? 10/30/2019

A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.

Customer Reviews (3)

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Reviews
04/19/2022

    It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.

    05/23/2020

      Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.

      03/09/2020

        The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.

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