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Recombinant Human ACACA protein, His/MBP-tagged

Cat.No. : ACACA-374H
Product Overview : Recombinant Human ACACA(264-406 aa) fused with His/MBP tag was expressed in E. coli.
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Description : Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His/MBP
Form : Liquid in PBS
Protein length : 1206-1370 aa
Purity : SDS-PAGE >90%
Applications : WB Positive Control
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : ACACA acetyl-CoA carboxylase alpha [ Homo sapiens ]
Official Symbol : ACACA
Synonyms : ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha; ACC; ACAC; ACCA; ACACAD;
Gene ID : 31
mRNA Refseq : NM_198834
Protein Refseq : NP_942131
MIM : 200350
UniProt ID : Q13085

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the mechanism by which acetyl-CoA carboxylase alpha protein performs its function? 10/09/2022

Acetyl-CoA carboxylase alpha protein performs its function through the transfer of a carboxyl group from bicarbonate to acetyl-CoA.

What are the physiological and pathological roles of acetyl-CoA carboxylase alpha protein? 04/04/2020

Acetyl-CoA carboxylase alpha protein plays important roles in energy metabolism, fatty acid synthesis, and insulin signaling.

How is the expression of acetyl-CoA carboxylase alpha protein regulated? 11/26/2019

The expression of acetyl-CoA carboxylase alpha protein is regulated by transcriptional and post-transcriptional mechanisms.

What is the relationship between acetyl-CoA carboxylase alpha protein and lipid metabolism? 06/16/2018

Acetyl-CoA carboxylase alpha protein is closely involved in the regulation of lipid metabolism.

How does acetyl-CoA carboxylase alpha protein interact with other cellular components and signaling pathways? 05/29/2018

Acetyl-CoA carboxylase alpha protein interacts with various cellular components, including cytoskeletal proteins and membrane lipids.

What is the significance of acetyl-CoA carboxylase alpha protein in human health and disease? 04/04/2017

Acetyl-CoA carboxylase alpha protein is implicated in various human diseases, such as obesity, diabetes, and cancer.

What is the primary function of acetyl-CoA carboxylase alpha protein? 02/27/2017

The primary function of acetyl-CoA carboxylase alpha protein is to catalyze the conversion of acetyl-CoA to malonyl-CoA.

Are there any potential therapeutic targets or strategies that could modulate the activity of acetyl-CoA carboxylase alpha protein? 05/03/2016

Modulating the activity of acetyl-CoA carboxylase alpha protein is a potential therapeutic strategy for metabolic disorders and cancer.

What is the structure of acetyl-CoA carboxylase alpha protein? 09/27/2015

Acetyl-CoA carboxylase alpha protein is a multi-subunit enzyme with a biotin carboxylase domain and a carboxyltransferase domain.

What are the cellular and molecular pathways involved in the regulation of acetyl-CoA carboxylase alpha protein? 03/24/2015

The regulation of acetyl-CoA carboxylase alpha protein involves multiple cellular pathways, including AMPK and mTOR signaling.

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