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Recombinant Human ACHE Protein, GST-Tagged

Cat.No. : ACHE-156H
Product Overview : Human ACHE full-length ORF ( AAH94752.1, 1 a.a. - 640 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 61.2 kDa
AA Sequence : MGTEKESPEPDCQKQFQAAVSVIQN LPKNGSYRPSYEEMLRFYSYYKQAT MGPCLVPRPGFWDPIGRYKWDAWNS LGKMSREEAMSAYITEMKLVAQKVI DTVPLGEVAEDMFGYFEPLYQVIPD MPRPPETFLRRVTGWKEQVVNGDVG AVSEPPCLPKEPAPPSPESHSPRDL DSEVFCDSLEQLEPELVWTEQRAAS GGKRDPRNSPVPPTKKEGLRGSPPG PQELDVWLLGTVRALQESMQEVQAR VQSLESMPRPPEQRPQPRPSARPWP LGLPGPALLFFLLWPFVVQWLFRMF RTQKR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ACHE acetylcholinesterase [ Homo sapiens ]
Official Symbol : ACHE
Synonyms : ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE;
Gene ID : 43
mRNA Refseq : NM_000665
Protein Refseq : NP_000656
MIM : 100740
UniProt ID : P22303

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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When can I receive the product after ordering? 02/08/2023

The time required for different proteins varies, you can pay attention to the information on the product details page, or contact our experts directly.

Can ACHE-3333HFL products change tags? 12/02/2022

Sure. We can customize proteins according to customer needs, including different tags, expression system, protein length, etc.

Why the protein length of ACHE-101H product is 1-351aa? 11/19/2022

Because we can customize proteins of different lengths according to customer needs, please contact us if you are interested in this product.

What is the mechanism by which patients with Alzheimer's disease are treated with acetylcholinesterase inhibitors? 04/26/2022

Patients with Alzheimer disease often receive treatment with acetylcholinesterase inhibitors that mitigate symptoms by hindering ACh turnover.

In which tissues is acetylcholinesterase mainly distributed? 04/14/2021

Acetylcholinesterase is known to be distributed in nervous tissue such as the brainstem, cerebellum, and peripheral and autonomic nervous systems. Skeletal muscle also contains AChE with distribution patterns seemingly related to the type of muscle (fast versus slow twitch) and their specific function. AChE is also present on red blood cell membranes.

Does ACHE only work on terminating neurotransmission? 03/16/2021

Although the primary function of AChE is to terminate neural transmission, investigators have found that AChE also plays a role in neural development. During fetal development, AChE contributes to morphogenesis in addition to its main enzymatic function.

What form does acetylcholinesterase usually exist in? 07/29/2020

Acetylcholinesterase exists as a monomer that often polymerizes into a dimer with a disulfide bond. Along with Van der Waals forces, two dimers may be linked to become tetramers.

What is the role of ACHE? 02/04/2020

The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. They are an important component of pesticides and nerve agents.

Customer Reviews (2)

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Reviews
12/12/2020

    I have already recommended creative biomart products to many colleagues.

    05/09/2019

      Received the product very quickly after placing the order, I am very satisfied.

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