Recombinant Human ACHE Protein, GST-Tagged
Cat.No. : | ACHE-156H |
Product Overview : | Human ACHE full-length ORF ( AAH94752.1, 1 a.a. - 640 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 61.2 kDa |
AA Sequence : | MGTEKESPEPDCQKQFQAAVSVIQN LPKNGSYRPSYEEMLRFYSYYKQAT MGPCLVPRPGFWDPIGRYKWDAWNS LGKMSREEAMSAYITEMKLVAQKVI DTVPLGEVAEDMFGYFEPLYQVIPD MPRPPETFLRRVTGWKEQVVNGDVG AVSEPPCLPKEPAPPSPESHSPRDL DSEVFCDSLEQLEPELVWTEQRAAS GGKRDPRNSPVPPTKKEGLRGSPPG PQELDVWLLGTVRALQESMQEVQAR VQSLESMPRPPEQRPQPRPSARPWP LGLPGPALLFFLLWPFVVQWLFRMF RTQKR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACHE acetylcholinesterase [ Homo sapiens ] |
Official Symbol : | ACHE |
Synonyms : | ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE; |
Gene ID : | 43 |
mRNA Refseq : | NM_000665 |
Protein Refseq : | NP_000656 |
MIM : | 100740 |
UniProt ID : | P22303 |
Products Types
◆ Recombinant Protein | ||
ACHE-106R | Recombinant Rat ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-2415H | Recombinant Human ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
Ache-511M | Recombinant Mouse Ache Protein, MYC/DDK-tagged | +Inquiry |
ACHE-04H | Active Recombinant Human ACHE Protein, His-tagged | +Inquiry |
ACHE-36R | Recombinant Rhesus Macaque ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
ACHE-8345H | Native Human ACHE | +Inquiry |
◆ Lysates | ||
ACHE-2163MCL | Recombinant Mouse ACHE cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0033 | Acetylcholinesterase Green Fluorescence Assay Kit | +Inquiry |
Kit-0032 | Acetylcholinesterase Assay Kit | +Inquiry |
Kit-0031 | Acetylcholinesterase Activity Colorimetric Assay Kit | +Inquiry |
Kit-0034 | Acetylcholinesterase Red Fluorescence Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionThe time required for different proteins varies, you can pay attention to the information on the product details page, or contact our experts directly.
Sure. We can customize proteins according to customer needs, including different tags, expression system, protein length, etc.
Because we can customize proteins of different lengths according to customer needs, please contact us if you are interested in this product.
Patients with Alzheimer disease often receive treatment with acetylcholinesterase inhibitors that mitigate symptoms by hindering ACh turnover.
Acetylcholinesterase is known to be distributed in nervous tissue such as the brainstem, cerebellum, and peripheral and autonomic nervous systems. Skeletal muscle also contains AChE with distribution patterns seemingly related to the type of muscle (fast versus slow twitch) and their specific function. AChE is also present on red blood cell membranes.
Although the primary function of AChE is to terminate neural transmission, investigators have found that AChE also plays a role in neural development. During fetal development, AChE contributes to morphogenesis in addition to its main enzymatic function.
Acetylcholinesterase exists as a monomer that often polymerizes into a dimer with a disulfide bond. Along with Van der Waals forces, two dimers may be linked to become tetramers.
The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. They are an important component of pesticides and nerve agents.
Customer Reviews (2)
Write a reviewI have already recommended creative biomart products to many colleagues.
Received the product very quickly after placing the order, I am very satisfied.
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