Recombinant Human ACTL6A Protein, GST-tagged

• Cat.No.: ACTL6A-222H
• Product Overview: Human ACTL6A partial ORF ( NP_817126, 1 a.a. - 80 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 34.54 kDa
• AA Sequence: MVVERDDGSTLMEIDGDKGKQGGPT YYIDTNALRVPRENMEAISPLKNGM VEDWDSFQAILDHTYKMHVKSEASL HPVLM
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACTL6A actin-like 6A [ Homo sapiens ]
• Official Symbol: ACTL6A
• Synonyms: ACTL6A; actin-like 6A; actin-like protein 6A; actin related protein 4; Actl6; Arp4; BAF complex 53 kDa subunit; BAF53A; Baf53a; BRG1 associated factor; INO80 complex subunit K; INO80K; BAF53; arpNbeta; hArpN beta; actin-related protein 4; BRG1-associated factor 53A; actin-related protein Baf53a; 53 kDa BRG1-associated factor A; ACTL6; ARPN-BETA
• Gene ID: 86
• mRNA Refseq: NM_004301
• Protein Refseq: NP_004292
• MIM: 604958
• UniProt ID: O96019