Recombinant Human AGER Protein, GST-tagged
Cat.No. : | AGER-423H |
Product Overview : | Human AGER full-length ORF ( AAH20669.1, 23 a.a. - 404 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 67.76 kDa |
AA Sequence : | AQNITARIGEPLVLKCKGAPKKPPQ RLEWNLNTGRTEAWKVLSPQGGGPW DSVARVLPNGSLFLPAVGIQDEGIF RCQAMNRNGKETKSNYRVRVYQIPG KPEIVDSASELTAGVPNKVGTCVSE GSYPAGTLSWHLDGKPLVPNEKGVS VKEQTRRHPETGLFTLQSELMVTPA RGGDPRPTFSCSFSPGLPRHRALRT APIQPRVWEPVPLEEVQLVVEPEGG AVAPGGTVTLTCEVPAQPSPQIHWM KDGVPLPLPPSPVLILPEIGPQDQG TYSCVATHSSHGPQESRAVSISIIE PGEEGPTAGSVGGSGLGTLALALGI LGGLGTAALLIGVILWQRRQRRGEE RKAPENQEEEEERAELNQSEEPEAG ESSTGGP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGER advanced glycosylation end product-specific receptor [ Homo sapiens ] |
Official Symbol : | AGER |
Synonyms : | AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; |
Gene ID : | 177 |
mRNA Refseq : | NM_001136 |
Protein Refseq : | NP_001127 |
MIM : | 600214 |
UniProt ID : | Q15109 |
Products Types
◆ Lysates | ||
AGER-2215MCL | Recombinant Mouse AGER cell lysate | +Inquiry |
AGER-1480HCL | Recombinant Human AGER cell lysate | +Inquiry |
AGER-2546HCL | Recombinant Human RAGE 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAGER is involved in bone metabolism and might influence osteoporosis and bone diseases.
AGER levels might serve as biomarkers for certain diseases, including diabetes.
AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.
AGER contributes to skin aging through oxidative stress and collagen damage.
AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.
Yes, AGER activation contributes to inflammation and immune responses.
AGER activation can impair wound healing through inflammation and oxidative stress.
AGER contributes to neuroinflammation and might play a role in neurodegeneration.
AGER contributes to diabetic nephropathy and kidney dysfunction.
AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.
AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.
Researchers explore compounds that modulate AGER to mitigate its effects.
AGER contributes to diabetic complications by promoting inflammation and tissue damage.
AGER is studied for its implications in aging, diabetes, and various age-related diseases.
AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).
Consuming a low-AGE diet may help reduce AGER activation and its negative effects.
AGER activation affects immune cell functions and influences immune responses.
AGER activation is linked to cardiovascular diseases, including atherosclerosis.
Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.
Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.
Customer Reviews (5)
Write a reviewIt's quality was evident in consistent results across replicates.
Protein consistently upregulated the expression of tissue-specific markers.
Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.
It’s consistent outcomes supported reliable statistical analysis.
Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.
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