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Recombinant Human AGTR1 Protein, GST-tagged

Cat.No. : AGTR1-447H
Product Overview : Human AGTR1 partial ORF ( AAH22447, 250 a.a. - 359 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 37.73 kDa
AA Sequence : FFSWIPHQIFTFLDVLIQLGIIRDC RIADIVDTAMPITICIAYFNNCLNP LFYGFLGKKFKRYFLQLLKYIPPKA KSHSNLSTKMSTLSYRHSDNVSSST KKPAPCFEVE
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AGTR1 angiotensin II receptor, type 1 [ Homo sapiens ]
Official Symbol : AGTR1
Synonyms : AGTR1; angiotensin II receptor, type 1; AGTR1B, angiotensin receptor 1B; type-1 angiotensin II receptor; AG2S; AGTR1A; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R; AT1AR; AT1BR; angiotensin receptor 1; angiotensin receptor 1B; angiotensin II type-1 receptor; type-1B angiotensin II receptor; AT1R; AGTR1B;
Gene ID : 185
mRNA Refseq : NM_000685
Protein Refseq : NP_000676
MIM : 106165
UniProt ID : P30556

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is AGTR1 involved in the regulation of renal function? 11/30/2021

AGTR1 activation in the kidneys leads to vasoconstriction of renal blood vessels, increased sodium reabsorption, and stimulation of aldosterone release, ultimately impacting renal function.

How does AGTR1 contribute to hypertension? 10/23/2021

Overactivation of AGTR1 can lead to increased vasoconstriction, sodium retention, and stimulation of aldosterone release, all of which contribute to hypertension.

What are the tissue distribution and expression of AGTR1? 02/13/2021

AGTR1 is widely expressed throughout the body, with high levels found in the cardiovascular system, kidneys, and adrenal glands.

Are there genetic variations in AGTR1 associated with disease susceptibility? 01/27/2021

Yes, genetic variations in the AGTR1 gene have been associated with increased susceptibility to cardiovascular diseases, hypertension, and other conditions influenced by the renin-angiotensin system.

Can AGTR1 influence inflammatory processes? 09/10/2020

AGTR1 activation can modulate inflammatory responses, contributing to inflammation-associated conditions such as atherosclerosis and chronic kidney disease.

How does AGTR1 signal within cells? 06/11/2020

Upon angiotensin II binding, AGTR1 activates intracellular signaling pathways, such as G-protein-mediated pathways and the activation of downstream kinases.

How does AGTR1 affect angiogenesis? 01/23/2020

AGTR1 activation can promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.

What are the downstream signaling pathways activated by AGTR1? 08/28/2019

AGTR1 can activate pathways such as the phosphoinositide 3-kinase (PI3K)/Akt pathway, mitogen-activated protein kinase (MAPK) pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.

Can AGTR1 be involved in cancer progression? 06/22/2019

AGTR1 has been implicated in cancer development and progression due to its role in cellular growth, angiogenesis, and inflammation.

How does AGTR1 contribute to oxidative stress? 05/02/2019

AGTR1 activation can promote the generation of reactive oxygen species, contributing to oxidative stress and cellular damage.

Customer Reviews (5)

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Reviews
09/28/2022

    It's like a ray of sunshine in our experiments, bringing joy and reliable data. A true delight to work with!

    09/02/2022

      I have been a loyal customer of this supplier for years due to their commitment to delivering proteins of exceptional quality at competitive prices.

      01/19/2021

        The post-sale services provided detailed technical support and ensured that I had a positive experience with their products.

        03/15/2020

          Love the affordable price and great quality of the recombinant proteins I purchased!

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