Recombinant Human AKAP12 Protein, GST-tagged

• Cat.No.: AKAP12-398H
• Product Overview: Human AKAP12 partial ORF ( NP_005091, 1675 a.a. - 1782 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.62 kDa
• AA Sequence: VPEDDGHALLAERIEKSLVEPKEDE KGDDVDDPENQNSALADTDASGGLT KESPDTNGPKQKEKEDAQEVELQEG KVHSESDKAITPQAQEELQKQERES AKSELTES
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AKAP12 A kinase (PRKA) anchor protein 12 [ Homo sapiens ]
• Official Symbol: AKAP12
• Synonyms: AKAP12; A kinase (PRKA) anchor protein 12; A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12; AKAP250; gravin; Src Suppressed C Kinase Substrate; SSeCKS; AKAP 250; kinase scaffold protein gravin; A-kinase anchor protein, 250kDa; Src-Suppressed C Kinase Substrate; myasthenia gravis autoantigen gravin; FLJ20945; FLJ97621; DKFZp686M0430; DKFZp686O0331
• Gene ID: 9590
• mRNA Refseq: NM_005100
• Protein Refseq: NP_005091
• MIM: 604698
• UniProt ID: Q02952