Recombinant Human AKT1 protein, His/MBP-tagged
| Cat.No. : |
AKT1-307H |
| Product Overview : |
Recombinant Human AKT1(13-253 aa) fused with His/MBP tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : |
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His/MBP |
| Form : |
Liquid in PBS |
| Protein length : |
13-253 aa |
| Purity : |
SDS-PAGE >90% |
| Applications : |
WB Positive Control |
| Stability : |
Samples are stable for up to twelve months from date of receipt at -70ºC. |
| Storage : |
Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
