Recombinant Human AMELY protein, MYC/DDK-tagged
Cat.No. : | AMELY-9645H |
Product Overview : | Recombinant Human AMELY fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
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- Gene Information
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Description : | This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 20 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | AMELY amelogenin, Y-linked [ Homo sapiens ] |
Official Symbol : | AMELY |
Synonyms : | Amelogenin (Y chromosome); Amelogenin; Amelogenin Y isoform; Amelogenin Y linked; AMELY; AMELY_HUMAN; AMGL; AMGY; Y isoform; AMELY |
Gene ID : | 266 |
mRNA Refseq : | NM_001143.1 |
Protein Refseq : | NP_001134 |
MIM : | 410000 |
UniProt ID : | Q99218 |
Chromosome Location : | Yp11.2 |
Function : | structural constituent of tooth enamel |
Products Types
◆ Recombinant Protein | ||
AMELY-9613H | Recombinant Human AMELY, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMELY is involved in tooth morphogenesis and differentiation by regulating the proliferation, differentiation, and mineralization processes during odontogenesis.
AMELY expression is specific to male individuals and absent in females.
The regulation of AMELY gene expression during dental development involves intricate interactions between transcription factors, hormonal signals, and genetic cascades.
Mutations or deletions in the AMELY gene can lead to dental abnormalities, specifically affecting male dental development, such as variations in tooth morphology or function.
AMELY interacts with other dental-specific proteins and signaling pathways, influencing tooth germ development, dental epithelial-mesenchymal interactions, and the formation of male-specific dental structures.
AMELY contributes to odontogenesis by influencing tooth crown morphology, establishing tooth shape, size, and structural organization characteristic of male dentition.
Manipulating AMELY expression or activity holds potential for developing therapeutic strategies targeting male dental abnormalities or gender-specific dental interventions, such as cosmetic dentistry or orthodontic treatments.
AMELY plays a crucial role in male-specific dental development, contributing to the formation and differentiation of dental tissues that exhibit sexual dimorphism.
AMELY undergoes post-translational modifications, including phosphorylation and glycosylation, which may impact its stability, localization, and interactions with other proteins involved in dental development and differentiation.
AMELY influences molecular pathways related to tooth mineralization and tissue maturation, participating in the regulation of dental matrix formation, enamel mineralization, and dentinogenesis processes.
Customer Reviews (3)
Write a reviewEnhanced assay sensitivity for detection of subtle protein changes.
Compatibility with complex biological matrices for translational research.
Accurate determination of protein function and activity.
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