Recombinant Human ANGPT4 protein, His & GST-tagged
Cat.No. : | ANGPT4-750H |
Product Overview : | Recombinant Human ANGPT4 aa. (Tyr305~Ile503 (Accession # Q9Y264)) fused with N-terminal His & GST tag was produced in E. coli cells. |
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Description : | Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. |
Source : | E. coli |
Species : | Human |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 54.9kDa |
Protein length : | Tyr305~Ile503 (Accession # Q9Y264) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 6.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | ANGPT4 angiopoietin 4 [ Homo sapiens (human) ] |
Official Symbol : | ANGPT4 |
Synonyms : | ANG3; ANG4; angiopoietin-4 |
Gene ID : | 51378 |
mRNA Refseq : | NM_001322809.1 |
Protein Refseq : | NP_001309738.1 |
UniProt ID : | Q9Y264 |
Products Types
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Angpt4-10520M | Recombinant Mouse Angpt4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ANGPT4-005H | Active Recombinant Human ANGPT4 Protein | +Inquiry |
ANGPT4-207H | Recombinant Human ANGPT4 Protein, Fc-tagged | +Inquiry |
ANGPT4-0113H | Recombinant Human ANGPT4 Protein (Tyr305-Ile503), N-GST-tagged | +Inquiry |
◆ Lysates | ||
ANGPT4-1318HCL | Recombinant Human ANGPT4 cell lysate | +Inquiry |
ANGPT4-1614HCL | Recombinant Human ANGPT4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionYes, Angpt4 has been linked to obesity and adipose tissue metabolism. It has been shown to be expressed in adipose tissue and plays a role in adipogenesis (the formation of fat cells) and adipocyte differentiation. Studies have demonstrated that Angpt4 levels are increased in obesity and metabolic disorders, suggesting its involvement in adipose tissue dysfunction and metabolic disturbances.
Research efforts have explored the diagnostic and prognostic potential of Angpt4 protein in various diseases. For example, in cancer, increased expression of Angpt4 has been correlated with poor prognosis and advanced disease stages. In cardiovascular diseases, higher Angpt4 levels have been associated with increased risk and severity of atherosclerosis. However, further studies are needed to establish its clinical utility as a biomarker.
Yes, Angpt4 has been implicated in cardiovascular disorders, such as atherosclerosis, which is characterized by the buildup of plaque in the arterial walls. Studies have shown that Angpt4 is involved in the regulation of vascular permeability and inflammation, which are important processes in atherosclerosis development. Its dysregulation can contribute to the progression of cardiovascular diseases.
While current research primarily focuses on cancer and cardiovascular disorders, there is growing interest in exploring the therapeutic potential of targeting Angpt4 in other diseases. This includes metabolic disorders, such as obesity and diabetes, as well as inflammatory conditions and neurodegenerative diseases. The exact role of Angpt4 in these diseases is still being investigated, but it holds promise as a potential therapeutic target in diverse pathologies.
The expression of Angpt4 protein is regulated by multiple factors, including growth factors, hormones, and cytokines. For example, vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) can upregulate Angpt4 expression. Additionally, transcription factors like HIF-1 (hypoxia-inducible factor-1) can influence the expression of Angpt4 in response to low oxygen levels.
As of now, there are limited clinical trials specifically targeting Angpt4 protein. However, there are clinical trials investigating the effectiveness of anti-angiogenic therapies that may indirectly affect Angpt4. These therapies aim to inhibit the formation of new blood vessels in tumors and are being tested in various cancer types. It is possible that future clinical trials may focus on specifically targeting Angpt4 to further assess its therapeutic potential.
Although there are no specific inhibitors or activators of Angpt4 approved for clinical use currently, research studies have identified potential molecules that can modulate Angpt4 activity. For example, one study showed that a compound called L1-7 can block Angpt4-induced endothelial cell migration and angiogenesis in vitro. Further research is needed to explore the therapeutic potential of these molecules.
As of now, there are no registered clinical trials specifically targeting Angpt4 protein. However, several studies are investigating the role of Angpt4 in different diseases, including cancer, cardiovascular disorders, and metabolic disorders. These studies aim to understand the potential therapeutic implications of targeting Angpt4 in these conditions.
Currently, there are limited reports of genetic mutations or alterations in Angpt4 directly associated with diseases. However, variations in the regulatory regions or expression levels of Angpt4 may contribute to disease susceptibility or severity. Further research is needed to explore the genetic aspects of Angpt4 and its potential implications in various diseases.
Currently, there is limited research on natural compounds or herbal extracts specifically targeting Angpt4 activity. However, natural compounds and herbal extracts are being studied for their potential angiogenic and anti-angiogenic effects, which indirectly may influence Angpt4 activity.
While there is limited research on Angpt4 specifically in wound healing, studies have suggested its involvement in the process. Angpt4 has been found to promote lymphatic vessel growth, and lymphatic vessels play a crucial role in wound healing by draining excess fluid and immune cells from the site of injury.
Gene therapy is a promising approach for targeting specific genes and their associated proteins, and it is possible to consider Angpt4 as a target for gene therapy. However, research on gene therapy specifically targeting Angpt4 is still limited. Gene therapy approaches could involve using viral vectors to introduce therapeutic genes that can modulate Angpt4 expression or using gene editing techniques to alter the genetic sequence of Angpt4. These approaches would require further investigation and testing to assess their feasibility and safety.
While there are no FDA-approved drugs targeting Angpt4, several research efforts are underway to develop therapies that can modulate Angpt4 activity. These include antibodies that can neutralize Angpt4 or inhibit its binding to its receptors. Additionally, small molecule inhibitors that can selectively block Angpt4 signaling are also being explored. These potential therapies are still in preclinical stages and would require further testing before their clinical use.
Angpt4 protein has been implicated in various physiological and pathological processes. It plays a significant role in embryonic development, particularly in angiogenesis and lymphangiogenesis. Additionally, abnormal expression or dysregulation of Angpt4 has been associated with several diseases, including cancer, cardiovascular disorders, and metabolic disorders such as obesity and diabetes.
Although there is ongoing research exploring the potential of Angpt4 as a diagnostic marker, it is not currently widely used for diagnostic purposes. However, there have been studies indicating its possible association with certain diseases. For example, elevated levels of Angpt4 have been found in patients with obesity and metabolic disorders, suggesting its potential as a biomarker in these conditions.
In addition to its role in angiogenesis, Angpt4 has been implicated in lymphangiogenesis, the formation of new lymphatic vessels. It has been shown to promote lymphatic vessel growth and regulate lymphatic endothelial cell function. Angpt4 is also involved in the regulation of endothelial cell permeability and inflammation, which are important in vascular integrity and immune responses. Further research is needed to fully understand the multifaceted functions of Angpt4.
Current research aims to delve deeper into the mechanisms of action and regulation of Angpt4 protein. Scientists are investigating its interactions with other angiogenic factors and signaling pathways to better understand its role in angiogenesis, lymphangiogenesis, and disease processes. Additionally, preclinical studies exploring the therapeutic potential of targeting Angpt4 in various diseases are ongoing to assess its efficacy and safety.
Customer Reviews (5)
Write a reviewTheir expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.
It can be seamlessly integrated into various molecular biology techniques, such as immunoassays, cell-based functional assays, and protein-protein interaction studies.
Its adaptability enables researchers to unravel the complex interplay and functional relevance of Angpt4 in different biological processes.
The prompt and precise support provided by the manufacturer ensures that researchers can proceed with their work smoothly, without any hindrances or uncertainties.
With the Angpt4 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.
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