Recombinant Human APBB1 protein, GST-tagged

• Cat.No.: APBB1-668H
• Product Overview: Human APBB1 full-length ORF ( NP_663722.1, 1 a.a. - 708 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 103.4 kDa
• AA Sequence: MSVPSSLSQSAINANSHGGPALSLP LPLHAAHNQLLNAKLQATAVGPKDL RSAMGEGGGPEPGPANAKWLKEGQN QLRRAATAHRDQNRNVTLTLAEEAS QEPEMAPLGPKGLIHLYSELELSAH NAANRGLRGPGLIISTQEQGPDEGE EKAAGEAEEEEEDDDDEEEEEDLSS PPGLPEPLESVEAPPRPQALTDGPR EHSKSASLLFGMRNSAASDEDSSWA TLSQGSPSYGSPEDTDSFWNPNAFE TDSDLPAGWMRVQDTSGTYYWHIPT GTTQWEPPGRASPSQGSSPQEESQL TWTGFAHGEGFEDGEFWKDEPSDEA PMELGLKEPEEGTLTFPAQSLSPEP LPQEEEKLPPRNTNPGIKCFAVRSL GWVEMTEEELAPGRSSVAVNNCIRQ LSYHKNNLHDPMSGGWGEGKDLLLQ LEDETLKLVEPQSQALLHAQPIISI RVWGVGRDSGRDFAYVARDKLTQML KCHVFRCEAPAKNIATSLHEICSKI MAERRNARCLVNGLSLDHSKLVDVP FQVEFPAPKNELVQKFQVYYLGNVP VAKPVGVDVINGALESVLSSSSREQ WTPSHVSVAPATLTILHQQTEAVLG ECRVRFLSFLAVGRDVHTFAFIMAA GPASFCCHMFWCEPNAASLSEAVQA ACMLRYQKCLDARSQASTSCLPAPP AESVARRVGWTVRRGVQSLWGSLKP KRLGAHTP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) [ Homo sapiens ]
• Official Symbol: APBB1
• Synonyms: APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; FE65; MGC:9072
• Gene ID: 322
• mRNA Refseq: NM_001164
• Protein Refseq: NP_001155
• MIM: 602709
• UniProt ID: O00213