Recombinant Human APC protein, GST-tagged
Cat.No. : | APC-12H |
Product Overview : | Recombinant Human APC(2744 a.a. - 2843 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 36.85 kDa |
AA Sequence : | NPVPVSETNESSIVERTPFSSSSSS KHSSPSGTVAARVTPFNYNPSPRKS SADSTSARPSQIPTPVNNNTKKRDS KTDSTESSGTQSPKRHSGSYLVTSV |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | APC adenomatous polyposis coli [ Homo sapiens ] |
Official Symbol : | APC |
Synonyms : | APC; adenomatous polyposis coli; adenomatosis polyposis coli; adenomatous polyposis coli protein; DP2; DP2.5; DP3; PPP1R46; protein phosphatase 1; regulatory subunit 46; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46; GS; BTPS2; |
Gene ID : | 324 |
mRNA Refseq : | NM_000038 |
Protein Refseq : | NP_000029 |
MIM : | 611731 |
UniProt ID : | P25054 |
Chromosome Location : | 5q21-q22 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Beta-catenin phosphorylation cascade, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; |
Function : | beta-catenin binding; NOT cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity; |
Products Types
◆ Recombinant Protein | ||
APC-1308H | Recombinant Human APC Protein (L407-S751), His tagged | +Inquiry |
APC-1307H | Recombinant Human APC Protein (L407-S751), Tag Free | +Inquiry |
Apc-544M | Recombinant Mouse Apc Protein, His-tagged | +Inquiry |
Apc-202R | Recombinant Rat Apc Protein, His-tagged | +Inquiry |
APC-200H | Recombinant Human APC Protein, His-tagged | +Inquiry |
◆ Lysates | ||
APC-90HCL | Recombinant Human APC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (20)
Ask a questionThe source of Apc is the genome of E. coli and other bacteria, and it is artificially prepared by recombinant technology.
Patients should be closely monitored during the use of Apc , and sudden adverse reactions should be stopped in time and treated accordingly.
The therapeutic mechanism of Apc is to achieve therapeutic effect by activating the internal normal repair mechanism of intestinal epithelial cells, which is different from the therapeutic mechanism of anti-inflammatory drugs.
Apc is more reliable and has fewer side effects than other treatments, and has more obvious efficacy.
The application prospect of Apc is very broad, and there is still a lot of room for development and application scenarios in the future.
The price of Apc varies according to different countries, regions and manufacturers, and there are generally specific prices for different levels.
The clinical trial of Apc involves the research scope and methods mainly including drug safety, drug dose and frequency of use, therapeutic effect and serum biology.
The methods to ensure the quality of Apc mainly include the GMP production management system and quality testing system of drug manufacturers.
The treatment effect of Apc varies from patient to patient and generally takes weeks or even months to show up.
Apc has good safety, clinical studies have found a low rate of side effects, and serious adverse reactions are extremely rare.
Apc therapy is mainly suitable for patients with related diseases such as colorectal cancer and inflammatory bowel disease.
Apc can cause immune response, but in a certain dose and use mode, can reduce the incidence of immune reaction.
The future research directions and challenges of Apc mainly include the improvement of drug dosage forms, the further improvement of efficacy and safety, and the reliability of clinical trial design and result interpretation.
The course of treatment of Apc is generally not interfered with by other drugs, but patients should promptly inform their physician of other drugs used.
The production process of Apc mainly includes gene recombination process and protein purification process.
Apc can activate the internal normal repair mechanism of intestinal epithelial cells and reduce intestinal inflammatory response, so as to have a therapeutic effect on related diseases.
Recombinant Apc protein is mainly used to treat related diseases such as colorectal cancer and inflammatory bowel disease.
The dose and frequency of Apc are determined according to the patient's clinical situation and treatment regimen. The clinician will instruct the patient on the dosage and frequency of use based on standard treatment and monitoring indicators.
The treatment plan of Apc can be combined with other treatments, but the specific plan needs to be given by the doctor according to the specific situation of the patient.
Side effects such as mild fever and local pain may occur during treatment with Apc , but usually do not require special attention.
Customer Reviews (4)
Write a reviewI appreciate the production process of APC, every step is strictly controlled, thus ensuring the quality and stability of the product.
I appreciate the quality of APC manufacturer's attention to the product, and their product repeatability is very good, which makes our experiment more smooth.
APC produced by them has good labeling effect and can be used for fluorescent labeling.
The background of APC in Western blot was very clean and showed good antibody specificity.
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