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Recombinant Human APOM protein, GST-tagged

Cat.No. : APOM-718H
Product Overview : Human APOM full-length ORF ( AAH20683, 23 a.a. - 188 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 44 kDa
AA Sequence : CPEHSQLTTLGVDGKEFPEVHLGQW YFIAGAAPTKEELATFDPVDNIVFN MAAGSAPMQLHLRATIRMKDGLCVP RKWIYHLTEGSTDLRTEGRPDMKTE LFSSSCPGGIMLNETGQGYQRFLLY NRSPHPPEKCVEEFKSLTSCLDSKA FLLTPRNQEACELSNN
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : APOM apolipoprotein M [ Homo sapiens ]
Official Symbol : APOM
Synonyms : APOM; apolipoprotein M; ApoM; G3a; NG20; protein G3a; NG20-like protein; alternative name: G3a, NG20; apo-M; HSPC336; MGC22400;
Gene ID : 55937
mRNA Refseq : NM_001256169
Protein Refseq : NP_001243098
MIM : 606907
UniProt ID : O95445

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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Can genetic variations in the APOM gene influence APOM protein levels? 02/24/2023

Yes, genetic variations in the APOM gene can impact APOM protein levels. Certain single nucleotide polymorphisms (SNPs) or mutations within the APOM gene have been associated with altered APOM expression levels. For example, specific APOM gene variants have been linked to lower APOM protein levels in plasma and changes in HDL cholesterol levels, which may contribute to cardiovascular disease risk.

Where is APOM protein primarily expressed? 11/11/2022

APOM protein is mainly expressed in the liver and kidneys. It is also present in other tissues, such as the intestines, adrenal glands, and spleen, but at lower levels.

Are there any known regulators of APOM protein expression? 08/27/2021

Yes, there are several known regulators of APOM protein expression. Transcription factors, such as hepatocyte nuclear factor 1 (HNF-1), liver X receptors (LXRs), and peroxisome proliferator-activated receptor gamma (PPARγ), have been identified as regulators of APOM gene expression. Additionally, factors like insulin, statins, and sex hormones (such as estrogen) can also influence APOM protein levels.

Are there any interactions between APOM protein and other proteins or molecules? 06/02/2021

Yes, APOM protein can interact with other proteins and molecules. In addition to binding to S1P, APOM has been shown to interact with components of the HDL particle, such as apolipoprotein A-I (apoA-I). It can also interact with enzymes involved in the metabolism of lipids, such as sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate lyase (S1PL), which regulate S1P levels.

Can APOM protein be used as a biomarker for any diseases? 07/21/2020

APOM protein has been investigated as a potential biomarker for certain diseases. Research suggests that APOM levels in plasma or HDL particles could be used as a biomarker for evaluating cardiovascular risk and predicting the progression of metabolic disorders. However, further studies are needed to establish its utility as a clinical biomarker.

Does APOM protein have any known genetic variants or mutations? 05/26/2020

Yes, there are several known genetic variants and mutations in the APOM gene. Some studies have linked certain APOM gene variants to altered levels of APOM protein, which can impact lipid metabolism and the risk of developing cardiovascular diseases.

Are there any drug targets related to APOM protein? 10/12/2019

Given the role of APOM protein in lipid metabolism and its association with cardiovascular diseases, it has been considered as a potential drug target. However, no specific drugs targeting APOM are currently available. Further research is needed to explore potential therapeutic strategies aimed at modulating APOM levels or function for clinical applications.

Are there any known therapeutic strategies targeting APOM protein? 08/16/2019

Currently, there are no approved therapeutic strategies specifically targeting APOM protein. However, given its involvement in lipid metabolism and cardiovascular health, manipulating APOM levels or function could hold therapeutic potential. Future research may explore approaches such as gene therapy, potential drug candidates, or interventions aimed at modulating APOM expression or its interaction with S1P to potentially impact lipid disorders and cardiovascular diseases.

Is APOM protein associated with any diseases? 05/15/2018

APOM protein has been implicated in various diseases, particularly those related to lipid metabolism and cardiovascular health. For example, low levels of APOM in HDL particles have been associated with increased risk of atherosclerosis, coronary artery disease, and impaired glucose metabolism.

Can APOM protein affect the composition of HDL particles? 08/01/2017

Yes, APOM protein can influence the composition of HDL particles. Its binding to S1P within HDL can modify the lipid content and structure of these particles. This, in turn, can impact the functionality and biological properties of HDL, such as its ability to promote reverse cholesterol transport and exert anti-inflammatory effects.

How is APOM protein involved in the metabolism of sphingosine-1-phosphate? 07/30/2017

APOM protein binds to sphingosine-1-phosphate (S1P) and helps transport it within high-density lipoprotein (HDL) particles. This interaction with APOM stabilizes S1P and allows it to circulate in the bloodstream, playing a role in various biological processes, including immune cell trafficking, angiogenesis, and vascular biology.

What cellular processes are influenced by APOM protein? 07/11/2016

APOM protein is involved in several cellular processes, including lipid metabolism, lipoprotein biogenesis and remodeling, immune cell activation and migration, endothelial cell integrity, and vascular homeostasis. Its interaction with S1P and its role in HDL metabolism have implications for various physiological and pathological processes, such as atherosclerosis, inflammation, and cardiovascular health.

Customer Reviews (4)

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Reviews
04/08/2021

    Securing a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the APOM protein offered by the manufacturer will fulfill my requirements.

    09/18/2018

      This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.

      05/18/2018

        the APOM protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.

        07/11/2016

          Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.

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