| Description : |
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
162.2 kDa |
| AA Sequence : |
MTKKEEPPPSRVPRAVRVASLLSEG EELSGDDQGDEEEDDHAYEGVPNGG WHTSSLSLSLPSTIAAPHPMDGPPG GSTPVTPVIKAGWLDKNPPQGSYIY QKRWVRLDTDHLRYFDSNKDAYSKR FISVACISHVAAIGDQKFEVITNNR TFAFRAESDVERKEWMQALQQAMAE QRARARLSSAYLLGVPGSEQPDRAG SLELRGFKNKLYVAVVGDKVQLYKN LEEYHLGIGITFIDMSVGNVKEVDR RSFDLTTPYRIFSFSADSELEKEQW LEAMQGAIAEALSTSEVAERIWAAA PNRFCADCGAPQPDWASINLCVVIC KRCAGEHRGLGAGVSKVRSLKMDRK VWTETLIELFLQLGNGAGNRFWAAN VPPSEALQPSSSPSTRRCHLEAKYR EGKYRRYHPLFGNQEELDKALCAAV TTTDLAETQALLGCGAGINCFSGDP EAPTPLALAEQAGQTLQMEFLRNNR TTEVPRLDSMKPLEKHYSVVLPTVS HSGFLYKTASAGKLLQDRRAREEFS RRWCVLGDGVLSYFENERAVTPNGE IRASEIVCLAVPPPDTHGFEHTFEV YTEGERLYLFGLESAEQAHEWVKCI AKAFVPPLAEDLLARDFERLGRLPY KAGLSLQRAQEGWFSLSGSELRAVF PEGPCEEPLQLRKLQELSIQGDSEN QVLVLVERRRTLYIQGERRLDFMGW LGAIQKAAASMGDTLSEQQLGDSDI PVIVYRCVDYITQCGLTSEGIYRKC GQTSKTQRLLESLRQDARSVHLKEG EQHVDDVSSALKRFLRDLPDGLFTR AQRLTWLEASEIEDEEEKVSRYREL LVRLPPVNRATVKALISHLYCVQCF SDTNQMNVHNLAIVFGPTLFQTDGQ DYKAGRVVEDLINHYVVVFSVDEEE LRKQREEITAIVKMRVAGTASGTQH AGDFICTVYLEEKKAETEQHIKVPA SMTAEELTLEILDRRNVGIREKDYW TCFEVNEREEAERPLHFAEKVLPIL HGLGTDSHLVVKKHQAMEAMLLYLA SRVGDTKHGMMKFREDRSLLGLGLP SGGFHDRYFILNSSCLRLYKEVRSQ RPWSGAPETSHRPEKEWPIKSLKVY LGVKKKLRPPTCWGFTVVHETEKHE KQQWYLCCDTQMELREWFATFLFVQ HDGLVWPSEPSRVSRAVPEVRLGSV SLIPLRGSENEMRRSVAAFTADPLS LLRNV |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
