Recombinant Human ARNT protein, His-tagged

• Cat.No.: ARNT-33H
• Product Overview: Recombinant Human ARNT(aa 1-474) fused with His tag was expressed in Yeast.

Specification

• Description: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
• Source: Yeast
• Species: Human
• Tag: His
• Form: 20 mM Tris, pH 8.0, 500 mM NaCl, 50% glycerol
• Molecular Mass: 54.83 kD
• AA Sequence: MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRAIKRRPGLDFD DDGEGNSKFL RCDDDQMSND KERFARSDDEQSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS
  ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLTDQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQPQSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK
  TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG SSSVDPVSVNRLSFVRNRCR NGLGSVKDGE PHFVVVHCTG YIKAWPPAGVSLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNVCQP
  TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFCHPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMRTSSFTFQNPY SDEIEYIICT NTNVKNSSQE PRPT
• Storage: Long term: -80 centigrade; Short term: -20 centigrade. Avoid freeze-thaw cycles.

Gene Information

• Gene Name: ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens ]
• Official Symbol: ARNT
• Synonyms: ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
• Gene ID: 405
• mRNA Refseq: NM_001668
• Protein Refseq: NP_001659
• MIM: 126110
• UniProt ID: P27540
• Chromosome Location: 1q21
• Pathway: Angiogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Renal cell carcinoma, organism-specific biosystem
• Function: aryl hydrocarbon receptor activity; aryl hydrocarbon receptor binding; protein binding; protein heterodimerization activity; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription coactivator activity; transcription factor binding