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Recombinant Human BCCIP Protein, GST-tagged

Cat.No. : BCCIP-131H
Product Overview : Human BCCIP full-length ORF ( AAH09771, 1 a.a. - 314 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 60.17 kDa
AA Sequence : MASRSKRRAVESGVPQPPDPPVQRD EEEEKEVENEDEDDDDSDKEKDEED EVIDEEVNIEFEAYSLSDNDYDGIK KLLQQLFLKAPVNTAELTDLLIQQN HIGSVIKQTDVSEDSNDDMDEDEVF GFISLLNLTERKGTQCVEQIQELVL RFCEKNCEKSMVEQLDKFLNDTTKP VGLLLSERFINVPPQIALPMYQQLQ KELAGAHRTNKPCGKCYFYLLISKT FVEAEKNNSKKKPSNKKKAALMFAN AEEEFFYEKAILKFNYSVQEESDTC LGGKWSFDDVPMTPLRTVMLIPGDK MNEIMDKLKEYLSV
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : BCCIP BRCA2 and CDKN1A interacting protein [ Homo sapiens ]
Official Symbol : BCCIP
Synonyms : BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIPbeta; TOK-1beta; TOK-1alpha; protein TOK-1; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; BRCA2 and Cip1/p21 interacting protein; TOK1; TOK-1;
Gene ID : 56647
mRNA Refseq : NM_016567
Protein Refseq : NP_057651
MIM : 611883
UniProt ID : Q9P287

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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