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Recombinant Human BCL2L1 protein

Cat.No. : BCL2L1-348H
Product Overview : Recombinant Human BCL2L1 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 20 mM Tris-HCl, pH 8.0, 5 % Trehalose.
Molecular Mass : Approximately 23.7 kDa, a single non-glycosylated polypeptide chain containing 211 amino acids.
Protein length : 211
AA Sequence : SQSNRELVVDFLSYKLSQKGYSWSQ FSDVEENRTEAPEGTESEMETPSAI NGNPSWHLADSPAVNGATGHSSSLD AREVIPMAAVKQALREAGDEFELRY RRAFSDLTSQLHITPGTAYQSFEQV VNELFRDGVNWGRIVAFFSFGGALC VESVDKEMQVLVSRIAAWMATYLND HLEPWIQENGGWDTFVELYGNNAAA ESRKGQERFNR
Endotoxin : Less than 0.1 EU/µg of rHuBcl-xL as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : BCL2L1
Official Symbol : BCL2L1
Synonyms : BCL2L1; BCL2-like 1; bcl-2-like protein 1; Bcl X; bcl xL; bcl xS; BCL2L; BCLX; PPP1R52; protein phosphatase 1; regulatory subunit 52; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092;
Gene ID : 598
mRNA Refseq : NM_001191
Protein Refseq : NP_001182
MIM : 600039
UniProt ID : Q07817

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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