Active Recombinant Human BCR/RET protein, GST-tagged
Cat.No. : | BCR-25H |
Product Overview : | Recombinant Human BCR/RET(1-426 (BCR); 713-end (RET)) fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | BCR-RET is a chimaeric fusion of BCR and RET genes generated by a balanced translocation of genes from t(10;22)(q11;q11) and this leads to aberrant activation of RET activity which can transform hematopoietic cells and skew the hematopoietic differentiation program towards the monocytic/macrophage lineage (1). The BCR-RET fusion is frequently found in chronic myelomonocytic leukemia (CMML) cases. The RET fusion genes seem to constitutively mimic the same signaling pathway as RAS mutations frequently involved in CMML. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 110 nmol/min/mg |
Molecular Mass : | 140 kDa |
Purity : | > 80% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name : | BCR breakpoint cluster region [ Homo sapiens ] |
Official Symbol : | BCR |
Synonyms : | BCR; breakpoint cluster region; BCR1, D22S11; breakpoint cluster region protein; ALL; CML; D22S662; PHL; renal carcinoma antigen NY-REN-26; BCR1; D22S11; FLJ16453; |
Gene ID : | 613 |
mRNA Refseq : | NM_004327 |
Protein Refseq : | NP_004318 |
MIM : | 151410 |
UniProt ID : | P11274 |
Chromosome Location : | 22q11 |
Pathway : | Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Pathways in cancer, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; |
Function : | ATP binding; GTPase activator activity; Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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