| Description : |
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene, but the full-length nature of some of these variants has not been determined. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
114.5 kDa |
| AA Sequence : |
MLQNVTPHNKLPGEGNAGLLGLGPE AAAPGKRIRKPSLLYEGFESPTMAS VPALQLTPANPPPPEVSNPKKPGRV TNQLQYLHKVVMKALWKHQFAWPFR QPVDAVKLGLPDYHKIIKQPMDMGT IKRRLENNYYWAASECMQDFNTMFT NCYIYNKPTDDIVLMAQTLEKIFLQ KVASMPQEEQELVVTIPKNSHKKGA KLAALQGSVTSAHQVPAVSSVSHTA LYTPPPEIPTTVLNIPHPSVISSPL LKSLHSAGPPLLAVTAAPPAQPLAK KKGVKRKADTTTPTPTAILAPGSPA SPPGSLEPKAARLPPMRRESGRPIK PPRKDLPDSQQQHQSSKKGKLSEQL KHCNGILKELLSKKHAAYAWPFYKP VDASALGLHDYHDIIKHPMDLSTVK RKMENRDYRDAQEFAADVRLMFSNC YKYNPPDHDVVAMARKLQDVFEFRY AKMPDEPLEPGPLPVSTAMPPGLAK SSSESSSEESSSESSSEEEEEEDEE DEEEEESESSDSEEERAHRLAELQE QLRAVHEQLAALSQGPISKPKRKRE KKEKKKKRKAEKHRGRAGADEDDKG PRAPRPPQPKKSKKASGSGGGSAAL GPSGFGPSGGSGTKLPKKATKTAPP ALPTGYDSEEEEESRPMSYDEKRQL SLDINKLPGEKLGRVVHIIQAREPS LRDSNPEEIEIDFETLKPSTLRELE RYVLSCLRKKPRKPYTIKKPVGKTK EELALEKKRELEKRLQDVSGQLNST KKPPKKANEKTESSSAQQVAVSRLS ASSSSSDSSSSSSSSSSSDTSDSDS G |
| Quality Control Test : |
12.5% SDS-PAGE Stained with Coomassie Blue. |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
