Recombinant Human BTK protein, Flag-tagged, Biotinylated
Cat.No. : | BTK-38H |
Product Overview : | Recombinant Human BTK [2-659(end) amino acids of accession number NP_000052.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated. |
- Specification
- Gene Information
- Related Products
Source : | Insect cell |
Species : | Human |
Tag : | Flag |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Molecular Mass : | 80 kDa |
Purity : | >95% as determined by SDS-PAGE and CBB staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ] |
Official Symbol : | BTK |
Synonyms : | BTK; ATK; PSCTK1; XLA; AT; BPK; IMD1; AGMX1 |
Gene ID : | 695 |
mRNA Refseq : | NM_000061 |
Protein Refseq : | NP_000052 |
MIM : | 300300 |
UniProt ID : | Q06187 |
Chromosome Location : | Xq21.33-q22 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; |
Function : | ATP binding; ATP binding; identical protein binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; |
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◆ Lysates | ||
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◆ Assay kits | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe development of drugs targeting BTK is currently in the clinical trial stage, including small molecule inhibitors against BTK and inhibitors targeting BTK signaling pathways.
In clinical practice, the expression level of BTK can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of lymphoma and leukemia, testing the expression level of BTK can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.
BTK proteins can help to gain insight into the mechanisms of B cell development and activation, as well as the pathogenesis of certain diseases such as lymphoma and leukemia. In addition, it is of great significance for the development of new drugs and treatment strategies.
BTK protein plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
Studies have shown that BTK protein can participate in the regulation of antiviral immune responses and affect the course of viral infection.
It can be used as a target for the development of new drugs, or as a drug carrier for the directional delivery of drugs.
Customer Reviews (3)
Write a reviewHigh purity, lack of impurities, in the experiment performance is very efficient.
Short half-life, more flexible dosage plan.
It's stable in all kinds of environments.
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