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Recombinant Human CADM3 Protein, His-tagged

Cat.No. : CADM3-185H
Product Overview : Recombinant Human CADM3(Asn25-His330), transcript variant 2, fused with His tag at N-terminal was expressed in HEK293.
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  • Gene Information
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Description : The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
Molecular Mass : 34.7 kDa
Protein length : Asn25-His330
Endotoxin : < 0.1 EU per µg protein as determined by LAL test
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Storage : Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Concentration : Resuspend the protein to the desired concentration in proper buffer.
Gene Name : CADM3 cell adhesion molecule 3 [ Homo sapiens ]
Official Symbol : CADM3
Synonyms : CADM3; cell adhesion molecule 3; IGSF4B, immunoglobulin superfamily, member 4B; BIgR; FLJ10698; Necl 1; NECL1; nectin like 1; SynCAM3; TSLL1; TSLC1-like 1; nectin-like 1; TSLC1-like protein 1; nectin-like protein 1; brain immunoglobulin receptor; synaptic cell adhesion molecule 3; immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Necl-1; synCAM3;
Gene ID : 57863
mRNA Refseq : NM_001127173
Protein Refseq : NP_001120645
MIM : 609743
UniProt ID : Q8N126

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the implications of CADM3 mutations or dysregulation in neurological diseases like autism or schizophrenia? 07/29/2022

Mutations or dysregulation of CADM3 have been linked to neurological disorders like autism spectrum disorders and schizophrenia, highlighting its significance in neural function.

Can you explain the structure of CADM3 and its interactions with other proteins or ligands in neural adhesion processes? 09/20/2021

CADM3 has extracellular domains responsible for adhesion. It interacts with other synaptic proteins like neurexins and neuroligins, contributing to synaptic adhesion and signaling.

How does CADM3 contribute to synaptic adhesion and plasticity, and why is this important for neurological research? 06/12/2020

CADM3 mediates synaptic adhesion and facilitates synaptic plasticity, which is essential for learning and memory processes. Understanding CADM3's role is critical for advancing our knowledge of neurological disorders and cognitive function.

What is the primary function of CADM3 in cellular processes, and where is it typically expressed in the body? 02/03/2019

CADM3, also known as SynCAM3, is a cell adhesion molecule that plays a crucial role in synapse formation and neural connectivity. It is primarily expressed in neural tissues, particularly in neurons.

How does CADM3 expression change during brain development, and what roles does it play in neural differentiation and circuit formation? 11/09/2018

CADM3 expression varies during brain development and contributes to neural differentiation and circuit formation, aiding in proper brain function.

Customer Reviews (3)

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08/04/2022

    The product's quality is exceptional.

    03/21/2020

      I couldn't be happier with the results I've seen.

      01/27/2018

        it's helped me achieve my fitness goals faster than I expected.

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