Recombinant Human CALB1 Protein, GST-Tagged
Cat.No. : | CALB1-0286H |
Product Overview : | Human CALB1 full-length ORF (NP_004920.1, 1 a.a. - 261 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 56.4 kDa |
AA Sequence : | MAESHLQSSLITASQFFEIWLHFDA DGSGYLEGKELQNLIQELQQARKKA GLELSPEMKTFVDQYGQRDDGKIGI VELAHVLPTEENFLLLFRCQQLKSC EEFMKTWRKYDTDHSGFIETEELKN FLKDLLEKANKTVDDTKLAEYTDLM LKLFDSNNDGKLELTEMARLLPVQE NFLLKFQGIKMCGKEFNKAFELYDQ DGNGYIDENELDALLKDLCEKNKQD LDINNITTYKKNIMALSDGGKLYRT DLALILCAGDN |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CALB1 calbindin 1, 28kDa [ Homo sapiens ] |
Official Symbol : | CALB1 |
Synonyms : | CALB1; calbindin 1, 28kDa; CALB; calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type; |
Gene ID : | 793 |
mRNA Refseq : | NM_004929 |
Protein Refseq : | NP_004920 |
MIM : | 114050 |
UniProt ID : | P05937 |
Products Types
◆ Recombinant Protein | ||
CALB1-485H | Recombinant Human CALB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Calb1-479M | Recombinant Mouse Calb1 Protein, His/GST-tagged | +Inquiry |
Calb1-480R | Recombinant Rat Calb1 Protein, His-tagged | +Inquiry |
CALB1-355H | Recombinant Human CALB1 Protein, His-tagged | +Inquiry |
CALB1-749R | Recombinant Rat CALB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CALB1-7897HCL | Recombinant Human CALB1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCALB1 is highly expressed in specific populations of neurons, such as Purkinje cells in the cerebellum and certain interneurons in the cortex and hippocampus.
CALB1 can influence neuronal excitability by buffering calcium ions and modulating the activity of calcium-dependent signaling pathways, which can impact synaptic transmission and plasticity.
CALB1 helps maintain precise calcium concentrations in neuronal compartments, ensuring proper calcium signaling and preventing calcium-induced cell damage.
CALB1 dysregulation can disrupt calcium homeostasis, leading to altered neuronal signaling, impaired synaptic plasticity, and increased susceptibility to excitotoxicity.
CALB1 possesses EF-hand calcium-binding motifs that undergo conformational changes upon calcium binding, allowing it to tightly and specifically bind calcium ions.
Customer Reviews (3)
Write a reviewReady-to-use proteins save time on sample preparation.
Reliable purity minimizes experimental variability.
These proteins are indispensable tools for research success.
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