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Recombinant Human CALB1 Protein, GST-Tagged

Cat.No. : CALB1-0286H
Product Overview : Human CALB1 full-length ORF (NP_004920.1, 1 a.a. - 261 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 56.4 kDa
AA Sequence : MAESHLQSSLITASQFFEIWLHFDA DGSGYLEGKELQNLIQELQQARKKA GLELSPEMKTFVDQYGQRDDGKIGI VELAHVLPTEENFLLLFRCQQLKSC EEFMKTWRKYDTDHSGFIETEELKN FLKDLLEKANKTVDDTKLAEYTDLM LKLFDSNNDGKLELTEMARLLPVQE NFLLKFQGIKMCGKEFNKAFELYDQ DGNGYIDENELDALLKDLCEKNKQD LDINNITTYKKNIMALSDGGKLYRT DLALILCAGDN
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CALB1 calbindin 1, 28kDa [ Homo sapiens ]
Official Symbol : CALB1
Synonyms : CALB1; calbindin 1, 28kDa; CALB; calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type;
Gene ID : 793
mRNA Refseq : NM_004929
Protein Refseq : NP_004920
MIM : 114050
UniProt ID : P05937

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there specific brain regions or cell types where CALB1 is particularly abundant? 02/02/2021

CALB1 is highly expressed in specific populations of neurons, such as Purkinje cells in the cerebellum and certain interneurons in the cortex and hippocampus.

How does CALB1 contribute to neuronal excitability and synaptic transmission at the molecular level? 10/11/2020

CALB1 can influence neuronal excitability by buffering calcium ions and modulating the activity of calcium-dependent signaling pathways, which can impact synaptic transmission and plasticity.

What is the role of CALB1 in intracellular calcium homeostasis within neurons? 03/15/2019

CALB1 helps maintain precise calcium concentrations in neuronal compartments, ensuring proper calcium signaling and preventing calcium-induced cell damage.

What are the consequences of CALB1 deficiency or dysregulation at the molecular level? 12/08/2018

CALB1 dysregulation can disrupt calcium homeostasis, leading to altered neuronal signaling, impaired synaptic plasticity, and increased susceptibility to excitotoxicity.

How does CALB1 bind calcium ions at the molecular level? 06/20/2018

CALB1 possesses EF-hand calcium-binding motifs that undergo conformational changes upon calcium binding, allowing it to tightly and specifically bind calcium ions.

Customer Reviews (3)

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Reviews
07/23/2021

    Ready-to-use proteins save time on sample preparation.

    11/30/2020

      Reliable purity minimizes experimental variability.

      04/02/2020

        These proteins are indispensable tools for research success.

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