Recombinant Human CBLC Protein, GST-Tagged

• Cat.No.: CBLC-0461H
• Product Overview: Human CBLC full-length ORF (AAH28915, 1 a.a. - 474 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 77.88 kDa
• AA Sequence: MALAVAPWGRQWEEARALGRAVRML QRLEEQCVDPRLSVSPPSLRDLLPR TAQLLREVAHSRRAAGGGGPGGPGG SGDFLLIYLANLEAKSRQVAALLPP RGRRSANDELFRAGSRLRRQLAKLA IIFSHMHAELHALFPGGKYCGHMYQ LTKAPAHTFWRESCGARCVLPWAEF ESLLGTCHPVEPGCTALALRTTIDL TCSGHVSIFEFDVFTRLFQPWPTLL KNWQLLAVNHPGYMAFLTYDEVQER LQACRDKPGSYIFRPSCTRLGQWAI GYVSSDGSILQTIPANKPLSQVLLE GQKDGFYLYPDGKTHNPDLTELGQA EPQQRIHVSEEQLQLYWAMDSTFEL CKICAESNKDVKIEPCGHLLCSCCL AAWQHSDSQTCPFCRCEIKGWEAVS IYQFHGQATAEDPGNSSDQEGRELE LGQVPLSAPPLPPRPDLPPRKPRNA QPKVRLLKGNSPPAALGPQDPAPA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CBLC Cbl proto-oncogene, E3 ubiquitin protein ligase C [ Homo sapiens ]
• Official Symbol: CBLC
• Synonyms: CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c, Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c; CBL-3; CBL-SL
• Gene ID: 23624
• mRNA Refseq: NM_001130852
• Protein Refseq: NP_001124324
• MIM: 608453
• UniProt ID: Q9ULV8