Active Recombinant Human CCL2 Protein

• Cat.No.: CCL2-0621H
• Product Overview: Human CCL2 (P13500, 24 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Description: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
• Source: E. coli
• Species: Human
• Form: Lyophlized
• Bio-activity: Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/mL.
• Molecular Mass: 9 kDa
• AA Sequence: QPDAINAPVTCCYNFTNRKISVQRL ASYRRITSSKCPKEAVIFKTIVAKE ICADPKQKWVQDSMDHLDKQTQTPK T
• Endotoxin: < 0.1 ng/μg (1 EU/μg)
• Purity: > 90% by SDS-PAGE and HPLC
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -20 centigrade on dry atmosphere. After reconstitution with deionized water, store at 4 centigrade for one month. For long term storage store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: Lyophlized from 0.02 M Tris-HCl, pH 7.5 (20% glycerol)

Gene Information

• Gene Name: CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ]
• Official Symbol: CCL2
• Synonyms: CCL2; chemokine (C-C motif) ligand 2; SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); C-C motif chemokine 2; GDCF 2; HC11; MCAF; MCP 1; MCP1; MGC9434; monocyte chemoattractant protein 1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; homologous to mouse Sig je; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys Cys); member 2; SMC CF; small-inducible cytokine A2; monocyte chemoattractant protein-1; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
• Gene ID: 6347
• mRNA Refseq: NM_002982
• Protein Refseq: NP_002973
• MIM: 158105
• UniProt ID: P13500