Recombinant Human CCND1 Protein, GST-Tagged

• Cat.No.: CCND1-0658H
• Product Overview: Human CCND1 full-length ORF (AAH01501, 1 a.a. - 295 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 58.19 kDa
• AA Sequence: MEHQLLCCEVETIRRAYPDANLLND RVLRAMLKAEETCAPSVSYFKCVQK EVLPSMRKIVATWMLEVCEEQKCEE EVFPLAMNYLDRFLSLEPVKKSRLQ LLGATCMFVASKMKETIPLTAGKLC IYTDNSIRPEELLQMELLLVNKLKW NLAAMTPHDFIEHFLSKMPEAEENK QIIRKHAQTFVALCATDVKFISNPP SMVAAGSVVAAVQGLNLRSPNNFLS YYRLTRFLSRVIKCDPDCLRACQEQ IEALLESSLRQAQQNMDPKAAEEEE EEEEEVDLACTPTDVRDVDI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) [ Homo sapiens ]
• Official Symbol: CCND1
• Synonyms: CCND1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); BCL1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), D11S287E, PRAD1; B cell CLL/lymphoma 1; G1/S specific cyclin D1; parathyroid adenomatosis 1; U21B31; BCL-1; PRAD1; D11S287E
• Gene ID: 595
• mRNA Refseq: NM_053056
• Protein Refseq: NP_444284
• MIM: 168461
• UniProt ID: P24385