Recombinant Human CCR10 Protein, GST-Tagged

• Cat.No.: CCR10-0688H
• Product Overview: Human CCR10 full-length ORF (AAH98132.1, 1 a.a. - 362 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 64.8 kDa
• AA Sequence: MGTEATEQVSWGHYSGDEEDAYSAE PLPELCYKADVQAFSRAFQPSVSLT VAALGLAGNGLVLATHLAARRAARS PTSAHLLQLALADLLLALTLPFAAA GALQGWSLGSATCRTISGLYSASFH AGFLFLACISADRYVAIARALPAGP RPSTPGRAHLVSVIVWLLSLLLALP ALLFSQDGQREGQRRCRLIFPEGLT QTVKGASAVAQVALGFALPLGVMVA CYALLGRTLLAARGPERRRALRVVV ALVAAFVVLQLPYSLALLLDTADLL AARERSCPASKRKDVALLVTSGLAL ARCGLNPVLYAFLGLRFRQDLRRLL RGGSCPSGPQPRRGCPRRPRLSSCS APTETHSLSWDN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CCR10 chemokine (C-C motif) receptor 10 [ Homo sapiens ]
• Official Symbol: CCR10
• Synonyms: CCR10; chemokine (C-C motif) receptor 10; G protein coupled receptor 2, GPR2; C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2; GPR2
• Gene ID: 2826
• mRNA Refseq: NM_016602
• Protein Refseq: NP_057686
• MIM: 600240
• UniProt ID: P46092