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Recombinant Human CCR8 Protein, GST-Tagged

Cat.No. : CCR8-0698H
Product Overview : Human CCR8 full-length ORF (NP_005192.1, 1 a.a. - 355 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 67.2 kDa
AA Sequence : MDYTLDLSVTTVTDYYYPDIFSSPC DAELIQTNGKLLLAVFYCLLFVFSL LGNSLVILVLVVCKKLRSITDVYLL NLALSDLLFVFSFPFQTYYLLDQWV FGTVMCKVVSGFYYIGFYSSMFFIT LMSVDRYLAVVHAVYALKVRTIRMG TTLCLAVWLTAIMATIPLLVFYQVA SEDGVLQCYSFYNQQTLKWKIFTNF KMNILGLLIPFTIFMFCYIKILHQL KRCQNHNKTKAIRLVLIVVIASLLF WVPFNVVLFLTSLHSMHILDGCSIS QQLTYATHVTEIISFTHCCVNPVIY AFVGEKFKKHLSEIFQKSCSQIFNY LGRQMPRESCEKSSSCQQHSSRSSS VDYIL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CCR8 chemokine (C-C motif) receptor 8 [ Homo sapiens ]
Official Symbol : CCR8
Synonyms : CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973;
Gene ID : 1237
mRNA Refseq : NM_005201
Protein Refseq : NP_005192
MIM : 601834
UniProt ID : P51685

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of C-C chemokine receptor type 8 (CCR8) in the immune system? 05/01/2021

C-C chemokine receptor type 8 (CCR8) primarily functions in the immune system, playing a role in immune responses and cell migration.

How does CCR8 influence the balance between immune tolerance and inflammation? 03/24/2021

CCR8 plays a role in influencing the balance between immune tolerance and inflammation through its impact on T cell function.

What diseases or conditions are associated with dysregulation or abnormal expression of CCR8? 11/19/2020

Dysregulation or abnormal expression of CCR8 is associated with conditions like allergic diseases, autoimmune disorders, and certain cancers.

In which immune cells is CCR8 predominantly expressed? 08/16/2020

CCR8 is predominantly expressed in certain immune cells, including regulatory T cells (Tregs) and certain subsets of T lymphocytes.

How does CCR8 contribute to the regulation of immune responses and cell migration? 04/01/2019

CCR8 contributes to the regulation of immune responses and cell migration by responding to specific chemokines in the microenvironment.

Are there specific chemokines that bind to CCR8, and what is their role in immune modulation? 11/23/2018

Specific chemokines, such as CCL1, bind to CCR8, influencing immune modulation and cell trafficking.

Are there therapeutic implications or potential targets related to CCR8 in immune-related disorders? 03/29/2016

There are potential therapeutic implications related to CCR8 in immune-related disorders, making it a target of interest for drug development.

Customer Reviews (3)

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Reviews
09/26/2019

    The product's forward-thinking design was aligned with our lab's aspirations for cutting-edge research.

    09/21/2019

      The minimal variation across different batches enhanced the repeatability of our results.

      10/26/2016

        The product's ease of integration into our existing experimental setups minimized disruptions to our established processes.

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