Recombinant Human CCR8 Protein, GST-Tagged
Cat.No. : | CCR8-0698H |
Product Overview : | Human CCR8 full-length ORF (NP_005192.1, 1 a.a. - 355 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 67.2 kDa |
AA Sequence : | MDYTLDLSVTTVTDYYYPDIFSSPC DAELIQTNGKLLLAVFYCLLFVFSL LGNSLVILVLVVCKKLRSITDVYLL NLALSDLLFVFSFPFQTYYLLDQWV FGTVMCKVVSGFYYIGFYSSMFFIT LMSVDRYLAVVHAVYALKVRTIRMG TTLCLAVWLTAIMATIPLLVFYQVA SEDGVLQCYSFYNQQTLKWKIFTNF KMNILGLLIPFTIFMFCYIKILHQL KRCQNHNKTKAIRLVLIVVIASLLF WVPFNVVLFLTSLHSMHILDGCSIS QQLTYATHVTEIISFTHCCVNPVIY AFVGEKFKKHLSEIFQKSCSQIFNY LGRQMPRESCEKSSSCQQHSSRSSS VDYIL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CCR8 chemokine (C-C motif) receptor 8 [ Homo sapiens ] |
Official Symbol : | CCR8 |
Synonyms : | CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973; |
Gene ID : | 1237 |
mRNA Refseq : | NM_005201 |
Protein Refseq : | NP_005192 |
MIM : | 601834 |
UniProt ID : | P51685 |
Products Types
◆ Recombinant Protein | ||
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CCR8-3018M | Recombinant Mouse Ccr8 Protein | +Inquiry |
CCR8-1078HFL | Recombinant Human CCR8 protein, His&Flag-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1162 | CCR8 CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionC-C chemokine receptor type 8 (CCR8) primarily functions in the immune system, playing a role in immune responses and cell migration.
CCR8 plays a role in influencing the balance between immune tolerance and inflammation through its impact on T cell function.
Dysregulation or abnormal expression of CCR8 is associated with conditions like allergic diseases, autoimmune disorders, and certain cancers.
CCR8 is predominantly expressed in certain immune cells, including regulatory T cells (Tregs) and certain subsets of T lymphocytes.
CCR8 contributes to the regulation of immune responses and cell migration by responding to specific chemokines in the microenvironment.
Specific chemokines, such as CCL1, bind to CCR8, influencing immune modulation and cell trafficking.
There are potential therapeutic implications related to CCR8 in immune-related disorders, making it a target of interest for drug development.
Customer Reviews (3)
Write a reviewThe product's forward-thinking design was aligned with our lab's aspirations for cutting-edge research.
The minimal variation across different batches enhanced the repeatability of our results.
The product's ease of integration into our existing experimental setups minimized disruptions to our established processes.
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