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Home > Products > Recombinant Proteins > Recombinant Human CD40 Protein, Fc-tagged

Recombinant Human CD40 Protein, Fc-tagged

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Fc(11)
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Cat.No.:
CD40-108H
Product Overview:
Recombinant Human CD40 Protein extracellular domain 21-193aa (signal peptide removed), fused with a C-terminal Fc tag, was expressed in CHO.
Description:
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
Source:
CHO
Species:
Human
Tag :
Fc
Predicted N Terminal:
Glu 21
Form:
Lyophilized from sterile PBS, pH 7.4.
Bio-activity:
Measured by its binding ability in a functional ELISA.
Molecular Mass:
The recombinant mature human CD40 protein consists of 405 amino acids and has a calculated molecular mass of 45.2 KD.
Endotoxin:
<1.0EU/ug, LAL method
Purity:
>95% (SDS-PAGE)
Stability:
Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage:
Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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