Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-097-1828   Email: info@creative-biomart.com
Home > Products > Recombinant Proteins > Recombinant Human CD40 Protein, Fc-tagged

Recombinant Human CD40 Protein, Fc-tagged

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Cat.No.:
CD40-017H
Product Overview:
Recombinant human CD40 Fc Chimera (rhCD40-Fc) Met1-Arg193 (Accession # NP_001241.1) was produced in human HEK293 cells.
Description:
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Source:
HEK293 cells
Species:
Human
Tag :
Fc
Molecular Mass:
rhCD40-Fc was fused with Fc region of human IgG1 at C-terminal and has a calculated MW of 45.3 kDa expressed. The predicted N-terminal is Glu21. Protein migrates as 55-60 kDa in reduced SDS-PAGE resulting from glycosylation.
Endotoxin:
Less than 1.0 EU per 1 µg of the rhCD40-Fc by the LAL method.
Purity:
>95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Notes:
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Storage:
Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhCD40 centigradeFc should be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer:
Bulk protein in a 0.22 µm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.0 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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