Recombinant Human CD47 protein
Cat.No. : | CD47-7865H |
Product Overview : | Recombinant Human CD47(Met1-Pro139) fused with six amino acids (LEVLFQ) at the C-terminus was expressed in HEK293. |
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Description : | CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus. |
Source : | HEK293 |
Species : | Human |
Predicted N Terminal : | Gln 19 |
Form : | Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements. |
Molecular Mass : | The recombinant human CD47 consists 128 amino acids and predicts a molecular mass of 14.5 kDa. |
Protein length : | Met1-Pro139 |
Endotoxin : | <1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70°C |
Storage : | Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | CD47 CD47 molecule [ Homo sapiens ] |
Official Symbol : | CD47 |
Synonyms : | CD47; CD47 molecule; CD47 antigen (Rh related antigen, integrin associated signal transducer) , MER6; leukocyte surface antigen CD47; antigen identified by monoclonal 1D8; antigenic surface determinant protein OA3; CD47 glycoprotein; IAP; integrin associated protein; OA3; Rh related antigen; Rh-related antigen; integrin-associated protein; integrin-associated signal transducer; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); MER6; |
Gene ID : | 961 |
mRNA Refseq : | NM_001777 |
Protein Refseq : | NP_942088 |
MIM : | 601028 |
UniProt ID : | Q08722 |
Chromosome Location : | 3q13.1-q13.2 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Hemostasis, organism-specific biosystem; Integrins in angiogenesis, organism-specific biosystem; Signal regulatory protein (SIRP) family interactions, organism-specific biosystem; |
Function : | protein binding; thrombospondin receptor activity; |
Products Types
◆ Recombinant Protein | ||
CD47-892M | Recombinant Mouse CD47 Protein (Met1-Lys140), RlgG Fc-tagged | +Inquiry |
CD47-0826H | Recombinant Human CD47 Protein, His-Flag-StrepII-Tagged | +Inquiry |
CD47-913R | Recombinant Rat CD47 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD47-642M | Recombinant Mouse CD47 Protein, Fc-tagged | +Inquiry |
CD47-14H | Active Recombinant Human CD47 Protein, hIgG/His-tagged | +Inquiry |
◆ Lysates | ||
CD47-1363RCL | Recombinant Rat CD47 cell lysate | +Inquiry |
CD47-850HCL | Recombinant Human CD47 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1706 | CD47:SIRP-α[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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