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Active Recombinant Human CDK2/CCNE2 protein, GST-tagged

Cat.No. : CDK2-CCNE2-311H
Product Overview : Recombinant full-length human CDK2 and CCNE2 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.
  • Specification
  • Gene Information
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Description : CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.
Source : Insect cell
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
Bio-activity : The specific activity of CDK2/CyclinE2 was determined to be 60nmol/min/mg as per activity protocol.
Molecular Mass : CDK2 ~58 kDa and CCNE2 ~72 kDa
Purity : The purity of CDK2/CCNE2 was determined to be >90% by densitometry.
Applications : Kinase Assay; WB
Stability : 1 year at -70 centigrade
Storage : Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μL
Gene Name : cyclin dependent kinase 2 [ Homo sapiens (human) ]; cyclin E2 [ Homo sapiens (human) ]
Official Symbol : CDK2; CCNE2
Synonyms : CDKN2; p33; CDK2; CCNE2; CyclinE2
Gene ID : 1017; 9134
mRNA Refseq : NM_001798; NM_057749
Protein Refseq : NP_001789; NP_001228
MIM : 116953; 603775
UniProt ID : P24941; P24864

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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