Recombinant Human CES1 Protein, GST-Tagged
Cat.No. : | CES1-1148H |
Product Overview : | Human CES1 full-length ORF (AAH12418, 1 a.a. - 566 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 87.78 kDa |
AA Sequence : | MWLPALVLATLAASAAWGHPSSPPV VDTVHGKVLGKFVSLEGFAQPVAIF LGIPFAKPPLGPLRFTPPQPAEPWS FVKNATSYPPMCTQDPKAGQLLSEL FTNRKENIPLKLSEDCLYLNIYTPA DLTKKNRLPVMVWIHGGGLMVGAAS TYDGLALAAHENVVVVTIQYRLGTW GFFSTGDEHSRGNWGHLDQVAALRW VQDNIASFGGNPGSVTIFGESAGGE SVSVLVLSPLAKNLFHRAISESGVA LTSVLVKKGDVKPLAEQIAITAGCK TTTSAVMVHCLRQKTEEELLETTLK MKFLSLDLQGDPRESQPLLGTVIDG MLLLKTPEELQAERNFHTVPYMVGI NKQEFGWLIPMLMSYPLSEGQLDQK TAMSLLWKSYPLVCIAKELIPEATE KYLGGTDDTVKKKDLFLDLIADVMF GVPSVIVARNHRDAGAPTYMYEFQY RPSFSSDMKPKTVIGDHGDELFSVF GAPFLKEGASEEEIRLSKMVMKFWA NFARNGNPNGEGLPHWPEYNQKEGY LQIGANTQAAQKLKDKEVAFWTNLF AKKAVEKPPQTEHIEL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CES1 carboxylesterase 1 [ Homo sapiens ] |
Official Symbol : | CES1 |
Synonyms : | CES1; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); liver carboxylesterase 1; CEH; CES1A1; CES1A2; CES2; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; SES1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; REH; TGH; ACAT; PCE-1; MGC117365; |
Gene ID : | 1066 |
mRNA Refseq : | NM_001025194 |
Protein Refseq : | NP_001020365 |
MIM : | 114835 |
UniProt ID : | P23141 |
Products Types
◆ Recombinant Protein | ||
CES1-106H | Active Recombinant Human CES1 Protein | +Inquiry |
CES1-602H | Recombinant Human CES1 Protein, His-tagged | +Inquiry |
CES1-3200H | Recombinant Human CES1 Protein, MYC/DDK-tagged | +Inquiry |
CES1-13H | Active Recombinant Human CES1 Protein (His19-Glu563), C-10×His tagged | +Inquiry |
CES1-748H | Active Recombinant Human CES1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CES1-7564HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
CES1-7565HCL | Recombinant Human CES1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0207 | Carboxylesterase 1 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
Customer Reviews (3)
Write a reviewReliable for lab work.
Great value for quality.
Good quality, great service.
Ask a Question for All CES1 Products
Required fields are marked with *
My Review for All CES1 Products
Required fields are marked with *
Inquiry Basket