Recombinant Human CHN1 Protein, GST-Tagged

• Cat.No.: CHN1-1256H
• Product Overview: Human CHN1 full-length ORF (NP_001813.1, 1 a.a. - 459 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 79.6 kDa
• AA Sequence: MALTLFDTDEYRPPVWKSYLYQLQQ EAPHPRRITCTCEVENRPKYYGREF HGMISREAADQLLIVAEGSYLIRES QRQPGTYTLALRFGSQTRNFRLYYD GKHFVGEKRFESIHDLVTDGLITLY IETKAAEYIAKMTINPIYEHVGYTT LNREPAYKKHMPVLKETHDERDSTG QDGVSEKRLTSLVRRATLKENEQIP KYEKIHNFKVHTFRGPHWCEYCANF MWGLIAQGVKCADCGLNVHKQCSKM VPNDCKPDLKHVKKVYSCDLTTLVK AHTTKRPMVVDMCIREIESRGLNSE GLYRVSGFSDLIEDVKMAFDRDGEK ADISVNMYEDINIITGALKLYFRDL PIPLITYDAYPKFIESAKIMDPDEQ LETLHEALKLLPPAHCETLRYLMAH LKRVTLHEKENLMNAENLGIVFGPT LMRSPELDAMAALNDIRYQRLVVEL LIKNEDILF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CHN1 chimerin (chimaerin) 1 [ Homo sapiens ]
• Official Symbol: CHN1
• Synonyms: CHN1; chimerin (chimaerin) 1; CHN, Duane retraction syndrome 2, DURS2; N-chimaerin; ARHGAP2; Chimerin 1 (GTPase activating protein; rho; 2); n chimerin; RhoGAP2; n-chimerin; A-chimaerin; a2-chimaerin; alpha-chimerin; Rho GTPase-activating protein 2; NC; CHN; DURS2; RHOGAP2
• Gene ID: 1123
• mRNA Refseq: NM_001025201
• Protein Refseq: NP_001020372
• MIM: 118423
• UniProt ID: P15882