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Recombinant Human CLDN4 Protein, GST-tagged

Cat.No. : CLDN4-1443H
Product Overview : Human CLDN4 full-length ORF ( AAH00671, 1 a.a. - 209 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 48.73 kDa
AA Sequence : MASMGLQVMGIALAVLGWLAVMLCC ALPMWRVTAFIGSNIVTSQTIWEGL WMNCVVQSTGQMQCKVYDSLLALPQ DLQAARALVIISIIVAALGVLLSVV GGKCTNCLEDESAKAKTMIVAGVVF LLAGLMVIVPVSWTAHNIIQDFYNP LVASGQKREMGASLYVGWAASGLLL LGGGLLCCNCPPRTDKPYSAKYSAA RSAAASNYV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CLDN4 claudin 4 [ Homo sapiens ]
Official Symbol : CLDN4
Synonyms : CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein; CPER; CPE-R; CPETR; CPETR1; hCPE-R;
Gene ID : 1364
mRNA Refseq : NM_001305
Protein Refseq : NP_001296
MIM : 602909
UniProt ID : O14493

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential therapeutic implications of targeting CLDN4 in cancer treatment? 10/10/2022

Inhibiting CLDN4 function could enhance the efficacy of existing cancer therapies and potentially lead to the development of new treatment strategies.

How does CLDN4 protein contribute to the pathogenesis of infectious diseases? 01/16/2021

CLDN4 is involved in regulating the entry of certain pathogens into host cells, making it a potential target for the development of antiviral and antibacterial therapies.

Can CLDN4 protein be targeted for the treatment of autoimmune diseases? 10/01/2017

Research is underway to explore the potential of targeting CLDN4 to modulate tissue barrier function and alleviate the symptoms of autoimmune diseases.

How can CLDN4 protein be utilized in the diagnosis and management of IBD? 09/06/2017

Monitoring CLDN4 levels and function may provide valuable insights into the progression of IBD and help in the development of targeted therapies.

In what other clinical settings is CLDN4 protein being investigated? 08/18/2017

CLDN4 is also being studied in the context of kidney disease, skin disorders, and neurodegenerative diseases due to its role in maintaining tissue barrier function.

Customer Reviews (3)

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Reviews
08/05/2021

    The CLDN4 protein showcases outstanding quality, ensuring its suitability for addressing my experimental requirements effectively.

    06/02/2019

      the manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.

      06/25/2016

        Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.

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