Recombinant Human CLK1 Protein, GST-tagged
Cat.No. : | CLK1-1491H |
Product Overview : | Human CLK1 full-length ORF ( NP_004062.2, 1 a.a. - 484 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 83.7 kDa |
AA Sequence : | MRHSKRTYCPDWDDKDWDYGKWRSS SSHKRRKRSHSSAQENKRCKYNHSK MCDSHYLESRSINEKDYHSRRYIDE YRNDYTQGCEPGHRQRDHESRYQNH SSKSSGRSGRSSYKSKHRIHHSTSH RRSHGKSHRRKRTRSVEDDEEGHLI CQSGDVLSARYEIVDTLGEGAFGKV VECIDHKAGGRHVAVKIVKNVDRYC EAARSEIQVLEHLNTTDPNSTFRCV QMLEWFEHHGHICIVFELLGLSTYD FIKENGFLPFRLDHIRKMAYQICKS VNFLHSNKLTHTDLKPENILFVQSD YTEAYNPKIKRDERTLINPDIKVVD FGSATYDDEHHSTLVSTRHYRAPEV ILALGWSQPCDVWSIGCILIEYYLG FTVFPTHDSKEHLAMMERILGPLPK HMIQKTRKRKYFHHDRLDWDEHSSA GRYVSRRCKPLKEFMLSQDVEHERL FDLIQKMLEYDPAKRITLREALKHP FFDLLKKSI |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CLK1 CDC-like kinase 1 [ Homo sapiens ] |
Official Symbol : | CLK1 |
Synonyms : | CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY; CLK; STY; CLK/STY; |
Gene ID : | 1195 |
mRNA Refseq : | NM_001162407 |
Protein Refseq : | NP_001155879 |
MIM : | 601951 |
UniProt ID : | P49759 |
Products Types
◆ Recombinant Protein | ||
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CLK1-1759M | Recombinant Mouse CLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CLK1-1490H | Active Recombinant Human CLK1 Protein, GST-His-tagged | +Inquiry |
CLK1-3585M | Recombinant Mouse CLK1 Protein | +Inquiry |
◆ Lysates | ||
CLK1-7441HCL | Recombinant Human CLK1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1571 | CLK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLK1 expression is tightly regulated at transcriptional and post-translational levels, ensuring its proper function in normal cellular processes.
Researchers often measure CLK1 activity through in vitro kinase assays or by monitoring its phosphorylation targets in cellular or tissue samples.
Yes, studies suggest that CLK1 inhibitors may have therapeutic potential for neurodegenerative disorders by modulating RNA splicing.
Some studies suggest that CLK1 mutations may be associated with certain diseases, but further research is needed to establish clear links.
Yes, several CLK1 inhibitors are in preclinical and clinical development as potential anticancer agents.
Customer Reviews (3)
Write a reviewThe manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.
From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.
The CLK1 protein offers several advantageous features that make it an ideal choice for researchers conducting trials.
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