Active Recombinant Human CMA1 protein, His-tagged
Cat.No. : | CMA1-25H |
Product Overview : | Recombinant Human CMA1(Met1-Asn247) fused with His tag at C-terminal was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | Chymases are a group of chymotrypsin-like serine proteases secreted by mast cells. They are synthesized as inactive precursors containing a 2-residue propeptide, which needs to be removed by dipeptidyl peptidase I/cathepsin C for the enzymatic activity. Human Chymase encoded by the CMA1 gene is known to be involved in hypertention and heart failure through its ability to convert angiotensin I (Ang I) to angiotensin II (Ang II), which plays a key role in the regulation of arterial pressure. In addition, it is also important in physiological and pathological conditions including inflammation, fibrosis and processing of cytokines. Therefore, designing a specific inhibitor for Chymase activity has been a pharmacologic strategy to develop therapeutic agents. |
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Gly20 |
Form : | Supplied as a 0.2 μm filtered solution in HEPES and NaCl. |
Bio-activity : | Measured by its ability to cleave the fluorogenic peptide substrate, SUC-Ala-Ala-Pro-Phe-AMC. The specific activity is >80 pmol/min/µg, as measured under the described conditions. |
Molecular Mass : | Predicted Molecular Mass: 27 kDa; SDS-PAGE: 38 kDa, reducing conditions. |
Protein length : | Met1-Asn247 |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening. |
Shipping : | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | CMA1 chymase 1, mast cell [ Homo sapiens ] |
Official Symbol : | CMA1 |
Synonyms : | CMA1; chymase 1, mast cell; chymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; CYH; MCT1; MGC119890; MGC119891; |
Gene ID : | 1215 |
mRNA Refseq : | NM_001836 |
Protein Refseq : | NP_001827 |
MIM : | 118938 |
UniProt ID : | P23946 |
Chromosome Location : | 14 |
Pathway : | ACE Inhibitor Pathway, organism-specific biosystem; Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem; Signal Transduction, organism-specific biosystem; |
Function : | peptidase activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; |
Products Types
◆ Recombinant Protein | ||
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Cma1-211M | Recombinant Mouse Cma1 Protein, His-tagged | +Inquiry |
CMA1-412D | Recombinant Dog CMA1 Protein (22-249 aa), His-SUMO-tagged | +Inquiry |
CMA1-1530H | Recombinant Human CMA1 Protein, GST-tagged | +Inquiry |
CMA1-2111C | Recombinant Cynomolgus Monkey CMA1 Protein (22-247 aa), His-SUMO-tagged | +Inquiry |
◆ Native Protein | ||
CMA1-35H | Active Native Human CMA1 protein | +Inquiry |
◆ Lysates | ||
CMA1-493HCL | Recombinant Human CMA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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