Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CREBBP Protein, GST-tagged

Cat.No. : CREBBP-1852H
Product Overview : Human CREBBP partial ORF ( NP_004371, 951 a.a. - 1050 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : PVHAQPPGTPLSQAAASIDNRVPTP SSVASAETNSQQPGPDVPVLEMKTE TQAEDTEPDPGESKGEPRSEMMEED LQGASQVKEETDIAEQKSEPMEVDE
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CREBBP CREB binding protein [ Homo sapiens ]
Official Symbol : CREBBP
Synonyms : CREBBP; CREB binding protein; RSTS, Rubinstein Taybi syndrome; CREB-binding protein; CBP; KAT3A; RTS; RSTS;
Gene ID : 1387
mRNA Refseq : NM_001079846
Protein Refseq : NP_001073315
MIM : 600140
UniProt ID : Q92793

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Why is the discovery of new CREBBP inhibitors urgent? 07/20/2022

Discovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.

What is the significance of the bromodomain in CREBBP? 06/27/2022

The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.

What does CREBBP stand for? 08/25/2020

CREBBP stands for CREB-binding protein.

What is the role of CREBBP in cellular function? 03/19/2019

CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.

What is the current status of CREBBP small molecule inhibitors? 04/03/2016

Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.

In which category of structural domain proteins does CREBBP belong? 02/14/2016

CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.

How many structural domains does CREBBP have? 02/01/2016

CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.

Customer Reviews (3)

Write a review
Reviews
04/17/2021

    The product's adaptability to custom protocols empowered us to explore innovative experimental setups.

    01/29/2019

      The reduced environmental impact of the product was a responsible choice that resonated with our values.

      11/15/2016

        Customized solutions offered by the manufacturer increased the product's utility in our research.

        Ask a Question for All CREBBP Products

        Required fields are marked with *

        My Review for All CREBBP Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends