Recombinant Human CREBBP Protein, GST-tagged
Cat.No. : | CREBBP-1852H |
Product Overview : | Human CREBBP partial ORF ( NP_004371, 951 a.a. - 1050 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | PVHAQPPGTPLSQAAASIDNRVPTP SSVASAETNSQQPGPDVPVLEMKTE TQAEDTEPDPGESKGEPRSEMMEED LQGASQVKEETDIAEQKSEPMEVDE |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CREBBP CREB binding protein [ Homo sapiens ] |
Official Symbol : | CREBBP |
Synonyms : | CREBBP; CREB binding protein; RSTS, Rubinstein Taybi syndrome; CREB-binding protein; CBP; KAT3A; RTS; RSTS; |
Gene ID : | 1387 |
mRNA Refseq : | NM_001079846 |
Protein Refseq : | NP_001073315 |
MIM : | 600140 |
UniProt ID : | Q92793 |
Products Types
◆ Recombinant Protein | ||
CREBBP-001H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
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CREBBP-22HCL | Recombinant Human CREBBP 293 Cell Lysate | +Inquiry |
CREBBP-847R | Recombinant Rhesus Macaque CREBBP Protein, His (Fc)-Avi-tagged | +Inquiry |
CREBBP-1022R | Recombinant Monkey Crebbp Protein, His tagged | +Inquiry |
◆ Assay kits | ||
Kit-1711 | CREBBP TR-FRET Assay Kit | +Inquiry |
Kit-1710 | CREBBP Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDiscovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.
The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.
CREBBP stands for CREB-binding protein.
CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.
Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.
CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.
CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.
Customer Reviews (3)
Write a reviewThe product's adaptability to custom protocols empowered us to explore innovative experimental setups.
The reduced environmental impact of the product was a responsible choice that resonated with our values.
Customized solutions offered by the manufacturer increased the product's utility in our research.
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