Recombinant Human CTLA4 protein, His-tagged
Cat.No. : | CTLA4-54H |
Product Overview : | Recombinant human CTLA4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | CTLA4, also known as cytotoxic T-lymphocyte-associated protein 4, is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. This protein is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. It has been implicated in several autoimmune diseases, such as systemic lupus erythematosus. |
Source : | Insect cells |
Species : | Human |
Tag : | His tag |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 20% glycerol. |
Molecular Mass : | 14.6kDa (135aa)18-28KDa (SDS–PAGE under reducing conditions.) |
AA Sequence : | ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDH HHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25mg/ml (determined by Absorbance at 280nm) |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Official Symbol : | CTLA4 |
Synonyms : | CTLA4; CD; CD28; CD152; GSE; ICOS; GRD4; CTLA-4; IDDM12; CELIAC3 |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
MIM : | |
UniProt ID : | P16410 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; |
Function : | protein binding; |
Products Types
◆ Recombinant Protein | ||
CTLA4-647C | Recombinant Cynomolgus monkey CTLA4 Protein | +Inquiry |
CTLA4-4413B | Recombinant Bovine CTLA4 Protein | +Inquiry |
Ctla4-3307M | Active Recombinant Mouse Ctla4 protein(Met1-Phe162), His-tagged | +Inquiry |
Ctla4-038M | Active Recombinant Mouse Ctla4 Protein, Fc-tagged | +Inquiry |
CTLA4-024H | Recombinant Human CTLA4 Protein, C-His-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
Ask a Question for All CTLA4 Products
Required fields are marked with *
My Review for All CTLA4 Products
Required fields are marked with *
Inquiry Basket