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Active Recombinant Human CXCL13 Protein

Cat.No. : CXCL13-024H
Product Overview : Purified recombinant protein of Human chemokine (C-X-C motif) ligand 13 (CXCL13)(Val23-Arg94) was expressed in E. coli.
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Description : Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. [UniProtKB/Swiss-Prot Function]
Source : E. coli
Species : Human
Bio-activity : Bioactivity was measured by its property to chemoattract Baf3-hCXCR5 transfectants in a dose dependent manner.
Molecular Mass : 8.6 kDa
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method.
Purity : > 98% as determined by Coomassie stained SDS-PAGE.
Concentration : Protein formulated and vialed at >50 µg/mL in specified buffer
Storage Buffer : 1 x PBS
Gene Name : CXCL13 chemokine (C-X-C motif) ligand 13 [ Homo sapiens ]
Official Symbol : CXCL13
Synonyms : CXCL13; chemokine (C-X-C motif) ligand 13; SCYB13, small inducible cytokine B subfamily (Cys X Cys motif), member 13 (B cell chemoattractant); C-X-C motif chemokine 13; ANGIE; ANGIE2; B cell chemoattractant; BCA 1; BLC; BLR1L; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); BCA1; BCA-1; SCYB13;
Gene ID : 10563
mRNA Refseq : NM_006419
Protein Refseq : NP_006410
MIM : 605149
UniProt ID : O43927

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is the expression pattern of CXCL13 protein related to the clinical prognosis of specific diseases? 11/28/2019

Expression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.

What are the expression characteristics of CXCL13 protein in immune cells? 10/23/2019

The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.

Is there a regulatory mechanism for CXCL13 protein expression during inflammation? 04/12/2019

The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.

What is the role of CXCL13 protein in lymph node metastasis? 04/11/2019

In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.

What are the implications of CXCL13 protein research for new drug development? 02/27/2019

CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.

What are the potential applications of CXCL13 protein in immunotherapy? 02/17/2019

The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.

Customer Reviews (3)

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Reviews
07/10/2021

    Stability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.

    06/21/2021

      The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.

      08/14/2019

        In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.

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