Active Recombinant Human CXCL13 Protein
Cat.No. : | CXCL13-024H |
Product Overview : | Purified recombinant protein of Human chemokine (C-X-C motif) ligand 13 (CXCL13)(Val23-Arg94) was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. [UniProtKB/Swiss-Prot Function] |
Source : | E. coli |
Species : | Human |
Bio-activity : | Bioactivity was measured by its property to chemoattract Baf3-hCXCR5 transfectants in a dose dependent manner. |
Molecular Mass : | 8.6 kDa |
Endotoxin : | Less than 0.01 ng per µg protein as determined by the LAL method. |
Purity : | > 98% as determined by Coomassie stained SDS-PAGE. |
Concentration : | Protein formulated and vialed at >50 µg/mL in specified buffer |
Storage Buffer : | 1 x PBS |
Gene Name : | CXCL13 chemokine (C-X-C motif) ligand 13 [ Homo sapiens ] |
Official Symbol : | CXCL13 |
Synonyms : | CXCL13; chemokine (C-X-C motif) ligand 13; SCYB13, small inducible cytokine B subfamily (Cys X Cys motif), member 13 (B cell chemoattractant); C-X-C motif chemokine 13; ANGIE; ANGIE2; B cell chemoattractant; BCA 1; BLC; BLR1L; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); BCA1; BCA-1; SCYB13; |
Gene ID : | 10563 |
mRNA Refseq : | NM_006419 |
Protein Refseq : | NP_006410 |
MIM : | 605149 |
UniProt ID : | O43927 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionExpression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.
The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.
The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.
In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.
CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.
The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.
Customer Reviews (3)
Write a reviewStability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.
The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.
In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.
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