Recombinant Human CXCR3 protein, GST-tagged

• Cat.No.: CXCR3-16H
• Product Overview: Recombinant Human CXCR3(1 a.a. - 368 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 67.1 kDa
• AA Sequence: MVLEVSDHQVLNDAEVAALLENFSS SYDYGENESDSCCTSPPCPQDFSLN FDRAFLPALYSLLFLLGLLGNGAVA AVLLSRRTALSSTDTFLLHLAVADT LLVLTLPLWAVDAAVQWVFGSGLCK VAGALFNINFYAGALLLACISFDRY LNIVHATQLYRRGPPARVTLTCLAV WGLCLLFALPDFIFLSAHHDERLNA THCQYNFPQVGRTALRVLQLVAGFL LPLLVMAYCYAHILAVLLVSRGQRR LRAMRLVVVVVVAFALCWTPYHLVV LVDILMDLGALARNCGRESRVDVAK SVTSGLGYMHCCLNPLLYAFVGVKF RERMWMLLLRLGCPNQRGLQRQPSS SRRDSSWSETSEASYSGL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CXCR3 chemokine (C-X-C motif) receptor 3 [ Homo sapiens ]
• Official Symbol: CXCR3
• Synonyms: CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R
• Gene ID: 2833
• mRNA Refseq: NM_001504
• Protein Refseq: NP_001495
• MIM: 300574
• UniProt ID: P49682
• Chromosome Location: Xq13
• Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: C-X-C chemokine receptor activity; G-protein coupled receptor activity; chemokine binding; chemokine receptor activity; receptor activity; signal transducer activity