Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CYB5A protein, His-tagged

Cat.No. : CYB5A-22H
Product Overview : Recombinant Human CYB5A(Met1-Asp134) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : Cytochrome b5 (CYB5A) is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. CYB5A contains one cytochrome b5 heme-binding domain and has two isoforms produced by alternative splicing. Isoform 1 is a sngle-pass membrane protein. Isoform 2 is located in cytoplasm. The defects in CYB5A can result in type IV hereditary methemoglobinemia.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1mM EDTA, pH 7.25.
AA Sequence : MGSSHHHHHHSSGLVPRGSHMAEQS DEAVKYYTLEEIQKHNHSKSTWLIL HHKVYDLTKFLEEHP GGEEVLREQAGGDATENFEDVGHST DAREMSKTFIIGELHPDDRPKLNKP PETLITTIDSSSSWW TNWVIPAISAVAVALMYRLYMAED
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : CYB5A cytochrome b5 type A (microsomal) [ Homo sapiens ]
Official Symbol : CYB5A
Synonyms : CYB5A; cytochrome b5 type A (microsomal); CYB5, cytochrome b 5 , cytochrome b5 (microsomal); cytochrome b5; type 1 cyt-b5; CYB5; MCB5;
Gene ID : 1528
mRNA Refseq : NM_001190807
Protein Refseq : NP_001177736
MIM : 613218
UniProt ID : P00167
Chromosome Location : 18q23
Pathway : Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Vitamin C (ascorbate) metabolism, organism-specific biosystem; gamma-linolenate biosynthesis II (animals), organism-specific biosystem; gamma-linolenate biosynthesis II (animals), conserved biosystem;
Function : aldo-keto reductase (NADP) activity; cytochrome-c oxidase activity; enzyme binding; heme binding; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can mutations in the CYB5A gene lead to clinical conditions? 05/05/2018

Yes, mutations in the CYB5A gene can lead to disorders such as methemoglobinemia, a condition characterized by the presence of elevated levels of methemoglobin in the blood.

What are the potential clinical implications of modulating CYB5A activity? 08/23/2017

Modulating CYB5A activity could have implications for drug efficacy, toxicity, and individualized drug dosing in clinical practice.

How does the expression of CYB5A vary in different populations? 07/10/2017

Studies have shown that the expression of CYB5A can vary among different populations, which could impact drug metabolism and response to medications.

Can CYB5A protein be a target for therapeutic interventions? 03/19/2017

Yes, given its importance in drug metabolism, the CYB5A protein could be a potential target for therapeutic interventions aimed at optimizing drug response and minimizing adverse effects.

Are there any drugs that specifically interact with CYB5A protein? 09/24/2016

Yes, certain drugs may interact with the CYB5A protein, affecting its activity and potentially leading to drug-drug interactions and altered metabolism.

Customer Reviews (3)

Write a review
Reviews
09/04/2020

    Its high quality greatly enhances the reliability and reproducibility of experimental data.

    04/08/2020

      Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.

      09/25/2016

        CYB5A protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.

        Ask a Question for All CYB5A Products

        Required fields are marked with *

        My Review for All CYB5A Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends