Recombinant Human CYB5A protein, His-tagged
Cat.No. : | CYB5A-22H |
Product Overview : | Recombinant Human CYB5A(Met1-Asp134) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Cytochrome b5 (CYB5A) is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. CYB5A contains one cytochrome b5 heme-binding domain and has two isoforms produced by alternative splicing. Isoform 1 is a sngle-pass membrane protein. Isoform 2 is located in cytoplasm. The defects in CYB5A can result in type IV hereditary methemoglobinemia. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1mM EDTA, pH 7.25. |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMAEQS DEAVKYYTLEEIQKHNHSKSTWLIL HHKVYDLTKFLEEHP GGEEVLREQAGGDATENFEDVGHST DAREMSKTFIIGELHPDDRPKLNKP PETLITTIDSSSSWW TNWVIPAISAVAVALMYRLYMAED |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | CYB5A cytochrome b5 type A (microsomal) [ Homo sapiens ] |
Official Symbol : | CYB5A |
Synonyms : | CYB5A; cytochrome b5 type A (microsomal); CYB5, cytochrome b 5 , cytochrome b5 (microsomal); cytochrome b5; type 1 cyt-b5; CYB5; MCB5; |
Gene ID : | 1528 |
mRNA Refseq : | NM_001190807 |
Protein Refseq : | NP_001177736 |
MIM : | 613218 |
UniProt ID : | P00167 |
Chromosome Location : | 18q23 |
Pathway : | Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Vitamin C (ascorbate) metabolism, organism-specific biosystem; gamma-linolenate biosynthesis II (animals), organism-specific biosystem; gamma-linolenate biosynthesis II (animals), conserved biosystem; |
Function : | aldo-keto reductase (NADP) activity; cytochrome-c oxidase activity; enzyme binding; heme binding; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
Cyb5a-427M | Recombinant Mouse Cyb5a Protein, MYC/DDK-tagged | +Inquiry |
CYB5A-947R | Recombinant Rhesus Macaque CYB5A Protein, His (Fc)-Avi-tagged | +Inquiry |
CYB5A-1359R | Recombinant Rat CYB5A Protein, His (Fc)-Avi-tagged | +Inquiry |
CYB5A-001H | Recombinant Human CYB5A Protein, His-tagged | +Inquiry |
CYB5A-2208H | Recombinant Human CYB5A Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CYB5A-7146HCL | Recombinant Human CYB5A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, mutations in the CYB5A gene can lead to disorders such as methemoglobinemia, a condition characterized by the presence of elevated levels of methemoglobin in the blood.
Modulating CYB5A activity could have implications for drug efficacy, toxicity, and individualized drug dosing in clinical practice.
Studies have shown that the expression of CYB5A can vary among different populations, which could impact drug metabolism and response to medications.
Yes, given its importance in drug metabolism, the CYB5A protein could be a potential target for therapeutic interventions aimed at optimizing drug response and minimizing adverse effects.
Yes, certain drugs may interact with the CYB5A protein, affecting its activity and potentially leading to drug-drug interactions and altered metabolism.
Customer Reviews (3)
Write a reviewIts high quality greatly enhances the reliability and reproducibility of experimental data.
Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.
CYB5A protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.
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