Recombinant Human CYP1A2 Protein, GST-tagged

• Cat.No.: CYP1A2-2245H
• Product Overview: Human CYP1A2 full-length ORF ( AAH67427.1, 1 a.a. - 516 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 84.9 kDa
• AA Sequence: MALSQSVPFSATELLLASAIFCLVF WVLKGLRPRVPKGLKSPPEPWGWPL LGHVLTLGKNPHLALSRMSQRYGDV LQIRIDSTPVLVLSRLDTIRQALVR QGDDFKGRPDLYTSTLITDGQSLTF STDSGPVWAARRRLAQNALNTFSIA SDPASSSSCYLEEHVSKEAKALISR LQELMAGPGHFDPYNQVVVSVANVI GAMCFGQHFPESSDEMLSLVKNTHE FVETASSGNPLDFFPILRYLPNPAL QRFKAFNQRFLWFLQKTVQEHYQDF DKNSVRDITGALFKHSKKGPRASGN LIPQEKIVNLVNDIFGAGFDTVTTA ISWSLMYLVTKPEIQRKIQKELDTV IGRERRPRLSDRPQLPYLEAFILET FRHSSFLPFTIPHSTTRDTTLNGFY IPKKCCVFVNQWQVNHDPELWEDPS EFRPERFLTADGTAINKPLSEKMML FGMGKRRCIGEVLAKWEIFLFLAIL LQQLEFSVPPGVKVDLTPIYGLTMK HARCEHVQARLRFSIN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens ]
• Official Symbol: CYP1A2
• Synonyms: CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 2; cytochrome P450 1A2; CP12; P3 450; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; P3-450; P450(PA)
• Gene ID: 1544
• mRNA Refseq: NM_000761
• Protein Refseq: NP_000752
• MIM: 124060
• UniProt ID: P05177