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Recombinant Human DCN protein, His-tagged

Cat.No. : DCN-57H
Product Overview : Recombinant human DCN, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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  • Gene Information
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Description : DCN, also known as decorin isoform, is a small secreted chondroitin/dermatan sulfate proteoglycan within the family of small leucine-rich proteoglycans (SLRPs). This protein has been implicated in matrix assembly and may suppress the growth of various tumor cell lines by inhibiting the epidermal growth factor receptor.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol
Molecular Mass : 37.1kDa (335aa)40-57kDa (SDS-PAGE under reducing conditions)
AA Sequence : DEASGIGPEV PDDRDFEPSL GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKVSPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK KLSYIRIADTNITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLHNNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYKH HHHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : >95% by SDS – PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Absorbance at 280nm)
Gene Name : DCN decorin [ Homo sapiens ]
Official Symbol : DCN
Synonyms : DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II; CSCD; PG40; PGII; PGS2;
Gene ID : 1634
mRNA Refseq : NM_001920
Protein Refseq : NP_001911
MIM : 125255
UniProt ID : P07585
Chromosome Location : 12q23
Pathway : TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem;
Function : collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein N-terminus binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the effect of targeted DCN delivery on tumor growth in a mouse model of breast cancer? 07/10/2022

Targeted DCN delivery in breast cancer models reduces tumor growth.

How does DCN modulate TGF-β signaling at the molecular level? 05/06/2022

DCN modulates TGF-β signaling, affecting fibrosis and cancer development.

How do variations in the glycosaminoglycan chains attached to DCN influence its interaction with growth factors? 12/11/2021

Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.

What are the cellular and molecular consequences of DCN gene silencing in fibroblasts? 12/07/2021

DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.

How do mechanical forces influence the function and localization of DCN in the cardiac extracellular matrix? 04/30/2021

Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.

Which proteins are differentially expressed in cells overexpressing DCN compared to control cells? 10/14/2019

Overexpression of DCN changes protein expression related to cell growth and matrix interactions.

What is the detailed three-dimensional structure of DCN when bound to collagen? 07/27/2018

DCN bound to collagen reveals binding sites essential for collagen structure.

Customer Reviews (3)

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Reviews
03/11/2020

    Excellent support for protein purification. Highly recommend this service.

    11/01/2019

      Efficient protein expression, quick turnaround time, and reliable results.

      10/14/2019

        Outstanding antibody validation; trustworthy for protein-protein interaction studies.

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