Recombinant Human DDR1 Protein, GST-tagged

• Cat.No.: DDR1-2454H
• Product Overview: Human DDR1 full-length ORF ( AAH08716.1, 22 a.a. - 876 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 119.79 kDa
• AA Sequence: MKGHFDPAKCRYALGMQDRTIPDSD ISASSSWSDSTAARHSRLESSDGDG AWCPAGSVFPKEEEYLQVDLQRLHL VALVGTQGRHAGGLGKEFSRSYRLR YSRDGRRWMGWKDRWGQEVISGNED PEGVVLKDLGPPMVARLVRFYPRAD RVMSVCLRVELYGCLWRDGLLSYTA PVGQTMYLSEAVYLNDSTYDGHTVG GLQYGGLGQLADGVVGLDDFRKSQE LRVWPGYDYVGWSNHSFSSGYVEME FEFDRLRAFQAMQVHCNNMHTLGAR LPGGVECRFRRGPAMAWEGEPMRHN LGGNLGDPRARAVSVPLGGRVARFL QCRFLFAGPWLLFSEISFISDVVNN SSPALGGTFPPAPWWPPGPPPTNFS SLELEPRGQQPVAKAEGSPTAILIG CLVAIILLLLLIIALMLWRLHWRRL LSKAERRVLEEELTVHLSVPGDTIL INNRPGPREPPPYQEPRPRGNPPHS APCVPNGSAYSGDYMEPEKPGAPLL PPPPQNSVPHYAEADIVTLQGVTGG NTYAVPALPPGAVGDGPPRVDFPRS RLRFKEKLGEGQFGEVHLCEVDSPQ DLVSLDFPLNVRKGHPLLVAVKILR PDATKNARNDFLKEVKIMSRLKDPN IIRLLGVCVQDDPLCMITDYMENGD LNQFLSAHQLEDKAAEGAPGDGQAA QGPTISYPMLLHVAAQIASGMRYLA TLNFVHRDLATRNCLVGENFTIKIA DFGMSRNLYAGDYYRVQGRAVLPIR WMAWECILMGKFTTASDVWAFGVTL WEVLMLCRAQPFGQLTDEQVIENAG EFFRDQGRQVYLSRPPACPQGLYEL MLRCWSRESEQRPPFSQLHRFLAED ALNTV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens ]
• Official Symbol: DDR1
• Synonyms: DDR1; discoidin domain receptor tyrosine kinase 1; CAK, discoidin domain receptor family, member 1 , EDDR1, NEP, NTRK4, PTK3A; epithelial discoidin domain-containing receptor 1; CD167; RTK6; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma kinase 10; tyrosine-protein kinase CAK; protein-tyrosine kinase RTK-6; neuroepithelial tyrosine kinase; PTK3A protein tyrosine kinase 3A; CD167 antigen-like family member A; neurotrophic tyrosine kinase, receptor, type 4; CAK; DDR; NEP; HGK2; PTK3; TRKE; EDDR1; MCK10; NTRK4; PTK3A
• Gene ID: 780
• mRNA Refseq: NM_001202521
• Protein Refseq: NP_001189450
• MIM: 600408
• UniProt ID: Q08345