Recombinant Human DNMT3B protein, GST-tagged
Cat.No. : | DNMT3B-74H |
Product Overview : | Recombinant Human DNMT3B protein, fused with N-terminal GST tag, was expressed in insect cell. |
- Specification
- Gene Information
- Related Products
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris/HCl pH 8.0, 150 mM NaCl, 3 mM DTT, 10% glycerol (v/v). |
Molecular Mass : | 121.6 kDa |
Protein length : | 2-853 |
Storage : | Store at -80°C. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles. |
Gene Name : | DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta [ Homo sapiens ] |
Official Symbol : | DNMT3B |
Synonyms : | DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; ICF; ICF1; M.HsaIIIB; |
Gene ID : | 1789 |
mRNA Refseq : | NM_001207055 |
Protein Refseq : | NP_001193984 |
MIM : | 602900 |
UniProt ID : | Q9UBC3 |
Chromosome Location : | 20q11.2 |
Pathway : | Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserv |
Function : | DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; DNA-methyltransferase activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (5)
Ask a questionTargeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.
Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.
Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.
DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.
Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.
Customer Reviews (3)
Write a reviewThe DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
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