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Recombinant Human DNMT3B protein, GST-tagged

Cat.No. : DNMT3B-74H
Product Overview : Recombinant Human DNMT3B protein, fused with N-terminal GST tag, was expressed in insect cell.
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  • Gene Information
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Source : Insect cell
Species : Human
Tag : GST
Form : 50 mM Tris/HCl pH 8.0, 150 mM NaCl, 3 mM DTT, 10% glycerol (v/v).
Molecular Mass : 121.6 kDa
Protein length : 2-853
Storage : Store at -80°C. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles.
Gene Name : DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta [ Homo sapiens ]
Official Symbol : DNMT3B
Synonyms : DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; ICF; ICF1; M.HsaIIIB;
Gene ID : 1789
mRNA Refseq : NM_001207055
Protein Refseq : NP_001193984
MIM : 602900
UniProt ID : Q9UBC3
Chromosome Location : 20q11.2
Pathway : Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserv
Function : DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; DNA-methyltransferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting DNMT3B for therapeutic purposes? 12/04/2022

Targeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.

Are there any genetic disorders associated with mutations in the DNMT3B gene? 03/29/2021

Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.

Can DNMT3B protein be used as a potential biomarker for cancer diagnosis or prognosis? 11/08/2020

Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.

How does DNMT3B protein contribute to epigenetic regulation in cells? 09/21/2018

DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.

What are the therapeutic implications of targeting DNMT3B in cancer treatment? 02/03/2018

Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.

Customer Reviews (3)

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Reviews
11/09/2020

    The DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    09/10/2020

      With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

      04/23/2019

        Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

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